|
Indications for a pathogenic role for CD4+ T cells in rheumatoid inflammation |
| Association of rheumatoid arthritis with HLA-DR4 and HLA-DR1 subtypes (shared epitope) |
| Enrichment of activated CD4+ memory T cells in peripheral blood, synovial membrane, and synovial fluid |
| Important role in disease initiation in several animal models of inflammatory arthritis |
| Clinical efficacy of appropriate T-cell directed therapies |
Skapenko et al. Arthritis Research & Therapy 2005 7(Suppl 2):S4 doi:10.1186/ar1703 |