Differentiation of CD4 T cells into specialized Th1 or Th2 effector cells. Upon activation with specific antigen, CD4 T cells proliferate and differentiate into either the Th1 or the Th2 subset. Th1 cells promote cellular immunity and are involved in the development of autoimmune diseases; Th2 cells mediate humoral immunity and are involved in allergic immune responses. IFN, interferon; IL, interleukin; Th, T-helper (cell).
Skapenko et al. Arthritis Research & Therapy 2005 7(Suppl 2):S4 doi:10.1186/ar1703