 ReviewModulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?Vivianne Malmström  , Christina Trollmo and Lars Klareskog Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden  author email corresponding author email
Arthritis Research & Therapy 2005,
7(Suppl 2):S15-S20doi:10.1186/ar1505 Abstract
Rheumatoid arthritis (RA) is a common destructive inflammatory disease that affects 0.5–1% of the population in many countries. Even though several new treatments have been introduced for patients with RA, a considerable proportion of patients do not benefit from these, and the need for alternative treatment strategies is clear. This review explores the potential for a therapy targeting the adaptive immune system by modulating co-stimulation of T cells with a CTLA4–Ig fusion protein (abatacept). | 
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