Figure 1.

PONDR^® predictions of disorder for four familiar human proteins. The SwissProt Accession Numbers [63] are given in parentheses. (a) Alpha-1-antitrypsin (P01009); (b) hemoglobin B (P02023); (c) calmodulin (P62158); (d) transthyretin precursor human (P02766). The line at PONDR^® score 0.5 defines the disorder threshold and is an arbitrary measure used to distinguish order from disorder. The PONDR^® predictor used here and in all other diagrams in this paper is VL-XT, which is the default predictor on the PONDR^® web site.