Table 1

Genes whose mRNA expression is differentially expressed in bone marrow-derived or synovium-derived cells

Gene

Fold changes versus day 0

Upregulated in bone marrow-derived cells

MIP-1β

40.5

IGF2

34.3

OX40 ligand

27.5

Neuregulin

26.8

Lymphotoxin-β

13.5

Acidic fibroblast growth factor

11.4

GAPDH

11.3

Lymphotoxin-α precursor

10.0

BIGH3

9.5

TRAIL

7.2

IFN-γ receptor

7.2

G-CSF

6.9

Glia-derived neurite-promoting factor (GDNPF)

6.4

IFN-α/β receptor β-subunit precursor

6.2

Hepatocyte growth factor

6.0

RPL13A

5.9

Platelet-activating factor receptor

5.6

Keratinocyte growth factor; FGF7

4.8

Endothelin receptor type A

4.5

IGF-binding protein 2 (IGFBP2)

4.1

Inhibin bA subunit precursor; activin bA subunit precursor

4.1

Apoptosis-related protein TFAR15

4.0

Related to receptor tyrosine kinase (RYK)

3.4

VEGFR1

3.3

IGF-binding protein 3 (IGFPB3)

3.0

Insulin-like growth factor I receptor (IGF1R)

2.9

Downregulated in bone marrow-derived cells

MIP2-α, GRO-β

-26.2

IL-8 precursor

-25.3

Tumor necrosis factor-inducible protein TSG-6

-13.8

βNGF

-11.9

Granulocyte chemotactic protein (GCP2)

-6.2

FLT3 ligand

-5.1

Leukocyte IFN-inducible peptide

-4.9

BMP-4 + BMP-2B

-4.7

Activin receptor-like kinase 1 (Alk1); transforming growth factor beta superfamily receptor I (TSR1)

-4.2

Tumor necrosis factor alpha

-4.0

TRAIL receptor 2; death receptor 5

-3.8

BMP3B; GDF10

-3.6

Ciliary neurotropic factor receptor (CNTFR)

-3.6

Tumor necrosis factor receptor (TNFR)

-3.3

B-cell growth factor 1 precursos (BCGF1)

-3.2

IL-13 precursor

-3.1

Transforming growth factor beta

-2.8

IL-6

-2.6

ERBB2 receptor protein-tyrosine kinase

-2.5

IFN regulatory factor

-2.3

Upregulation or downregulation refer to the fold increase higher than ratio 2 in bone marrow samples (n = 4) compared with synovial samples (n = 4), with a Mann-Whitney significance of 0.05.

Djouad et al. Arthritis Research & Therapy 2005 7:R1304   doi:10.1186/ar1827