Table 4 |
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|
Association between TNF-RII T676G single nucleotide polymorphism genotype and sTNFR levels released by T cells |
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| Genotype |
n (%) |
sTNF-RI (pg/ml) |
sTNF-RII (pg/ml) |
|
|
|||
| Unstimulated T cells |
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| TT |
38 (65.5) |
166.8 ± 57.8 |
582.2 ± 259.6 |
| TG |
15 (25.9) |
144.1 ± 78.2 |
428.1 ± 222.3 |
| GG |
5 (8.6) |
137.2 ± 68.9 |
398.8 ± 194.9 |
| Stimulated T cells |
|||
| TT |
38 (65.5) |
178.0 ± 57.9 |
998.3 ± 355.6 |
| TG |
15 (25.9) |
146.5 ± 75.5 |
769.5 ± 292.8 |
| GG |
5 (8.6) |
141.6 ± 75.7 |
724.4 ± 167.3 |
|
|
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|
Shown is the association between tumour necrosis factor receptor II (TNF-RII) T676G single nucleotide polymorphism genotype and soluble tumour necrosis factor (sTNFR) levels released by T cells isolated from rheumatoid arthritis (RA) patients (n = 58). sTNFR levels are expressed as mean ± standard deviation. Levels of sTNFR released into culture medium of isolated T cells exhibited a similar trend of decreasing levels of both receptors according to TNF-RII genotype (order: TT > TG > GG), although only the associations with sTNF-RII were significant (unstimulated and stimulated cells, respectively: P for trend = 0.049 and P for trend = 0.02; multiple regression analysis corrected for age, sex and disease duration). sTNF-RI, soluble tumor necrosis factor receptor I. |
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|
Glossop et al. Arthritis Research & Therapy 2005 7:R1227 doi:10.1186/ar1816 |
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