Figure 5.

VEGF levels in the serum are correlated with the extent of arthritis in rats. (a) VEGF levels in the serum are higher in control rats than in tetrathiomolybdate (TM)-treated rats (* P < 0.01). VEGF was analyzed by ELISA, as described in Materials and methods. Data represent the mean ± standard deviation. (b) A significant positive relationship between VEGF levels in the serum and the severity of pannus formation in hindlimbs of adjuvant-induced arthritis rats, which includes both the control group and the TM-treated group. VEGF, vascular endothelial growth factor.