|
Dipeptidyl peptidase IV/CD26 in rheumatoid arthritis |
|||||||
| Peripheral blood CD3+CD26+ |
Peripheral blood CD4+CD26+ |
Synovial fluid CD3+CD26+ |
Serum/plasma DPPIV activity (μmol/min/l) |
Synovial DPPIV activity (μmol/min/l) |
Notes |
Reference |
|
|
|
|||||||
| Controls |
12.9 ± 4.7 |
Ta1 antibody; all active with therapy |
[47] |
||||
| RA (active) |
40.2 ± 10.6 |
Ta1 antibody; all active with therapy |
[47] |
||||
| Controls |
58.2 ± 10.6 |
1F7 antibody; all active with therapy |
[47] |
||||
| RA (active) |
72.0 ± 8.8 |
1F7 antibody; all active with therapy |
[47] |
||||
| Controls |
12.3 ± 4.2 |
Ta1 antibody |
[49] |
||||
| OA |
8.1 ± 2.0 |
Ta1 antibody |
[49] |
||||
| RA (inactive) |
41.6 ± 23.1 |
Ta1 antibody |
[49] |
||||
| RA (active) |
62.2 ± 10.1 |
Ta1 antibody |
[49] |
||||
| Controls |
58.8 ± 9.0 |
1F7 antibody |
[123] |
||||
| OA |
49.0 ± 11.0 |
1F7 antibody |
[123] |
||||
| RA (inactive) |
60.6 ± 4.0 |
1F7 antibody |
[123] |
||||
| RA (active) |
75.9 ± 10.0 |
36.3 ± 10.0 |
1F7 antibody |
[123] |
|||
| OA |
36.7 ± 6.5 (CD26: 614 ± 157 ng/ml) |
14.6 ± 4.4 (CD26: 247 ± 25 ng/ml) |
[55] |
||||
| RA |
[55] |
||||||
| All |
26.7 ± 9.9 (CD26: 473 ± 176 ng/ml) |
16.1 ± 5.6 (CD26: 259 ± 80 ng/ml) |
[55] |
||||
| Non-inflammatory |
31.8 ± 12.7 (CD26: 558 ± 195 ng/ml) |
(n = 24; CRP < 20 mg/l) |
[55] |
||||
| Inflammatory |
22.4 ± 4.7 (CD26: 404 ± 139 ng/ml) |
(n = 17; CRP > 20 mg/l) |
[55] |
||||
| Controls |
41.3 ± 4.7 |
[32] |
|||||
| RA (active) |
34.5 ± 3.2 |
[32] |
|||||
| SLE |
29.9 ± 6.5 |
[32] |
|||||
| OA |
702.6 ± 41.2 mU/mg |
Synovial fluid |
[60] |
||||
| RA (active) |
549.6 ± 28.3 mU/mg |
Synovial fluid |
[60] |
||||
| Controls |
634 μmol/min/mol |
[36] |
|||||
| Sjogren's syndrome |
969 μmol/min/mol |
[36] |
|||||
| SLE |
650 μmol/min/mol |
[36] |
|||||
| RA (active) |
224 μmol/min/mol |
[36] |
|||||
| OA |
1.0 ± 1.4 nmol/min/mg |
Synovial membranes |
[54] |
||||
| RA (active) |
|||||||
| All grades |
1.1 ± 1.1 nmol/min/mg |
Synovial membranes |
[54] |
||||
| Grade 1 (0–10 ml fluid) |
1.8 ± 1.4 nmol/min/mg |
Synovial membranes |
[54] |
||||
| Grade 2 (10–20 ml fluid) |
0.9 ± 0.6 nmol/min/mg |
Synovial membranes |
[54] |
||||
| Grade 3 (> 20 ml fluid) |
0.6 ± 0.5 nmol/min/mg |
Synovial membranes |
[54] |
||||
|
CRP, C-reactive protein; DPP, dipeptidyl peptidase; OA, osteoarthritis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus. Values for peripheral blood CD3+CD26+, peripheral blood CD4+CD26+ and synovial fluid CD3+CD26+ are shown as % gated lymphocytes. | |||||||
Sedo et al. Arthritis Research & Therapy 2005 7:253 doi:10.1186/ar1852 |
|||||||