Table 3 |
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|
Induced hyperhemia in patients with systemic sclerosis or primary Raynaud's phenomenon and healthy controls |
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|
Healthy controls (n = 20) |
Primary RP (n = 20) |
SSc (n = 20) |
P-value |
|
|
|
||||
|
Amplitude of the thermal response (median cutaneous vascular conductance (mV/mm Hg), 10th-90th percentile) |
||||
|
Baseline |
7.2 (1.1–38) |
6.4 (1.4–26.3) |
5.2 (1.2–25.9) |
NS |
|
10 min thermal peak |
43.4 (23.2–63) |
42.6 (31–80.7) |
27 (14.7–51.4)a |
0.01 |
|
10–30 min thermal peak |
35.5 (12.2–55) |
37.2 (24.3–70.6) |
24.7 (13.5–51) |
0.09 |
|
44°C thermal peak |
43.1 (21.3–62.1) |
42.6 (31.6–74.3) |
25.4 (15–52.4)a |
0.01 |
|
Kinetics of the thermal response (median time, seconds) |
||||
|
Time to first thermal peak |
190 (125–230) |
160 (91–311) |
391 (171–1483)a |
0.0001 |
|
Time to second peak |
1458 (867–1949) |
1394 (967–1991) |
- |
NS |
|
|
||||
|
Amplitude of the response to sublingual nitroglycerin (median vascular conductance (mV/mm Hg), 10th-90th percentile) |
||||
|
Baseline |
14.1 (1.1–54.2) |
4.6 (0.8–32) |
11.5 (1.4–38) |
NS |
|
4 min peak |
16.5 (1.6–55) |
9.1 (1.2–34.5) |
16.8 (3.6–37.7) |
NS |
|
|
||||
|
Amplitude of the post-occlusive response (median cutaneous vascular conductance (mV/mm Hg), 10th-90th percentile) |
||||
|
Baseline conductance |
13 (1.3–49) |
4.8 (1.1–32) |
7.7 (1.4–30) |
NS |
|
Peak hyperhemic conductance |
36.8 (11–65) |
28.5 (9.3–49) |
25.1 (9.5–50.2)b |
0.05 |
|
Kinetics of the post-occlusive response (median time (seconds) 10th-90th percentile) |
||||
|
Time to peak hyperhemia |
34.3 (17.4–76.5) |
44.4 (19.8–104) |
108.5 (15–287)a |
0.003 |
|
Duration of hyperhemia |
165 (75–277) |
150 (97–345) |
225 (82–345) |
NS |
|
|
||||
|
Data are medians, with 10th and 90th percentiles in parentheses. Cutaneous blood flow is expressed as cutaneous conductance (mV/mm Hg). Local heating at 42°C was applied for 30 minutes, followed by 5 minutes heating at 44°C. The cutaneous blood conductance was measured on the left middle fingerpad. aP < 0.05 following Bonferroni's correction versus healthy controls and versus primary Raynaud's phenomenon (RP), Mann-Whitney test. bP < 0.05 following Bonferroni's correction versus healthy controls. SSc, systemic sclerosis. |
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|
Boignard et al. Arthritis Research & Therapy 2005 7:R1103 doi:10.1186/ar1785 |
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