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Variance component analysis of FS1-OA variation in Chuvashian pedigrees |
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| Parameter |
Estimate ± SE |
|
|
|
| Regression coefficients |
|
| Intercept |
|
| αm |
0.0000a |
| αf |
0.0633 ± 0.0294 |
| Age effect |
|
| β1m |
0.0519 ± 0.0011 |
| β1f |
0.0519b |
| Stature effect |
|
| β2m |
[0] |
| β2f |
[0] |
| Body weight effect |
|
| β3m |
[0] |
| β3f |
[0] |
| Variance components |
|
| VAD |
0.0654 ± 0.0208 (24.43%) |
| VSP |
0.0355 ± 0.0176 (13.26%) |
| VHS |
[0] |
| VSB |
[0] |
| VRS |
0.1668 ± 0.0219 (62.31%) |
| LRTc |
|
| χ2 |
9.88 |
| df |
7 |
| P |
0.84 |
|
Parameter estimates and corresponding asymptotic standard errors (SEs) are provided for the best fitting and most parsimonious genetic model. [ ] Parameter was fixed at the indicated value. αm and αf are sex-specific intercepts (m, males; f, females). βm and βf are sex-specific slopes. aParameter estimate reached the boundary. bParameter was fixed to be equal to the previous. cLRT for comparison of the most parsimonious and general model where all parameters were estimated. df, degrees of freedom; FS1-OA, first factor score obtained from principal component analysis of OA; LRT, likelihood ratio test; V, variation, due to additive genetic effect (VAD) or to common environment shared by parents (VSP), by siblings (VSB), or by all members of nuclear pedigrees/household (VHS). | |
Suk et al. Arthritis Research & Therapy 2005 7:R1082 doi:10.1186/ar1786 |
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