Table 1 |
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|
Functional properties of the tissue inhibitors of metalloproteinases (TIMPs) (based on reviews [1-4]) |
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| Property |
TIMP-1 |
TIMP-2 |
TIMP-3 |
TIMP-4 |
|
|
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| Approximate protein size |
28 kDa |
21 kDa |
24/27 kDa |
22 kDa |
| Localisation |
Soluble |
Soluble + cell surface |
Extracellular matrix |
Cell surface, tissue-specific |
| Intracellular activation |
Receptor(s) Nuclear translocation |
Receptor(s) |
No |
Not known |
| Proteinase type inhibition |
Secreted MMP, ADAMTS |
Secreted MMP, MT-MMP |
MT-MMP, ADAMTS |
Secreted MMP, MT-MMP |
| Apoptosis |
Inhibits (BCL-2 regulation) |
Inhibits |
Promotes (TACE, death receptors) |
Promotes |
| Angiogenesis |
Inhibits |
Inhibits |
Inhibits |
Inhibits |
| Proliferation |
Stimulates |
Stimulates |
Inhibits |
Stimulates |
| Tumour growth |
Promotes |
Promotes |
Inhibits |
Not known |
| Knockout mice |
Resistance to Pseudomonas infection |
Impaired pro-MMP2 activation |
Lung emphysema, chronic hepatitis. High TNF-α |
Not known |
|
|
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|
ADAMTS, a disintegrin and metalloproteinase domain with thrombospondin motifs; MMP, matrix metallproteinase; MT-MMP, membrane-type matrix metalloproteinase; TACE, tumour-necrosis-factor-α-converting enzyme; TIMP, tissue inhibitor of metalloproteinases; TNF, tumour necrosis factor. |
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|
Bokarewa et al. Arthritis Research & Therapy 2005 7:R1014 doi:10.1186/ar1771 |
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