Levels of HIF-1α mRNA in the articular cartilage from patients with osteoarthritis (OA). (a)Representative x-ray film of knee joint and safranin-O staining for hypoxia-inducible factor 1α(HIF-1α) in the degenerated region and intact region of articular cartilage from a 66-year-old woman with OA. Original magnification of histological sections × 200. (b) The mRNA levels of HIF-1α were higher in the degenerated regions than in the intact regions from the same OA sample.
Yudoh et al. Arthritis Research & Therapy 2005 7:R904 doi:10.1186/ar1765