Table 2 |
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|
Summary of disease-related data of perforin-deficient (pfp-/-) mice compared with pfp+/- and pfp+/+ mice |
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| Genotype (n) |
Day of onset |
Incidence (%) |
Severity |
Maxscore |
AUC |
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|
|
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| Day 50 |
Day 75 |
Day 82 |
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|
|
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| Pfp-/- (13) |
59 ± 4.9 |
54 |
0.9 ± 0.8 |
2.1 ± 1.6 |
3.0 ± 1.5a |
3.4 ± 1.4b |
31.9 ± 23.0c |
| Pfp+/- (14) |
52 ± 3.5 |
64 |
1.4 ± 0.6 |
3.8 ± 0.9 |
4.0 ± 0.9a |
5.6 ± 1.2b |
44.6 ± 12.3c |
| Pfp+/+ (14) |
53 ± 3.6 |
64 |
1.3 ± 0.4 |
5.2 ± 1.2 |
5.6 ± 0.9a |
7.3 ± 1.1b |
59.4 ± 16.7 |
|
|
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|
Evaluations and analyses were performed as described in Materials and methods. Maxscore was calculated as the mean of the maximum score value for each individual mouse of a given genotype. Data are group mean values ± SEM. Values with the same superscript letter are significantly different (P < 0.05). AUC, area under the curve. |
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|
Bauer et al. Arthritis Research & Therapy 2005 7:R877 doi:10.1186/ar1758 |
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