Table 2

Summary of disease-related data of perforin-deficient (pfp-/-) mice compared with pfp+/- and pfp+/+ mice

Genotype (n)
Day of onset
Incidence (%)
Severity
Maxscore
AUC









Day 50
Day 75
Day 82



Pfp-/- (13)
59 ± 4.9
54
0.9 ± 0.8
2.1 ± 1.6
3.0 ± 1.5a
3.4 ± 1.4b
31.9 ± 23.0c
Pfp+/- (14)
52 ± 3.5
64
1.4 ± 0.6
3.8 ± 0.9
4.0 ± 0.9a
5.6 ± 1.2b
44.6 ± 12.3c
Pfp+/+ (14)
53 ± 3.6
64
1.3 ± 0.4
5.2 ± 1.2
5.6 ± 0.9a
7.3 ± 1.1b
59.4 ± 16.7

Evaluations and analyses were performed as described in Materials and methods. Maxscore was calculated as the mean of the maximum score value for each individual mouse of a given genotype. Data are group mean values ± SEM. Values with the same superscript letter are significantly different (P < 0.05). AUC, area under the curve.

Bauer et al. Arthritis Research & Therapy 2005 7:R877   doi:10.1186/ar1758

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