Figure 2.

Histopathology of perforin-deficient pfp^-/- mice compared with pfp^+/- mice. (a) Joint of a pfp^-/- mouse with severe inflammation and erosions, stage 4. (b) Paw of a heterozygous mouse in the same stage of disease. (c) Comparison of histological and clinical evaluation of the disease. Data are values of severity of pfp^+/- mice (n = 6) and pfp^-/- mice (n = 6), and are shown as means ± SEM.