Table 2

Mitochondrial mutational burden data of OA and RA patient synoviocyte tissue and cultured fibroblasts


Number of mutations
 Total mutational burden (mutations/kbp)
 OA vs RAa


Mitochondrial mutational burden
 Nucleotides sequenced
 Initial
 Published polymorphisms removed
 Initial
 Published polymorphisms removed
 Initial
 Published Polymorphisms removed
Total
     Fibroblasts






          OA
 18489
 38
 20
 2.055
 1.082

          RA
 30503
 101
 65
 3.311
 2.131
 ρ = 0.01
 ρ = 6.9 × 10-3
     Tissue






          OA
 37145
 67
 40
 1.804
 1.077

          RA
 17663
 60
 42
 3.397
 2.378
 ρ = 4 × 10-4
 ρ = 5.1 × 10-4
Expressed
     Fibroblasts






          OA
 6956
 12
 7
 1.725
 1.006

          RA
 12394
 28
 26
 2.259
 2.098
 ρ = 0.5
 ρ = 0.10
     Tissue






          OA
 15805
 10
 10
 0.633
 0.633

          RA
 6397
 16
 14
 2.501
 2.189
 ρ = 6 × 10-4
 ρ = 2.7 × 10-3

aTwo-tailed Fisher's exact test. kbp, kilobase pairs; OA, osteoarthritis; RA, rheumatoid arthritis.

Da Sylva et al. Arthritis Research & Therapy 2005 7:R844   doi:10.1186/ar1752

Open Data