|
Characteristics of bone marrow lymphocytes were influenced both by ovariectomy and by arthritis |
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| Arthritis |
OVX |
n |
Bone marrow cellularity (× 106) |
B cells per femur (× 106) |
T cells per femur (× 106) |
CD4+ cells per femur (× 106) |
CD69+/CD4+ cells (%) |
CD8+ cells per femur (× 106) |
CD69+/CD8+ cells (%) |
|
|
|||||||||
| - |
- |
10 |
5.1 (4.0–6.4) |
1.5 (1.0–1.7)*** |
0.06 (0.05–0.09) |
0.02 (0.02–0.04) |
25 (18–30) |
0.013 (0.008–0.018) |
3 (1–3) |
| + |
10 |
6.0 (5.0–8.6) |
2.4 (2.0–3.0) |
0.05 (0.04–0.07) |
0.02 (0.02–0.03) |
29 (26–31) |
0.008 (0.006–0.012) |
4 (2–6) |
|
| + |
- |
18 |
5.2 (4.7–7.0) |
1.0 (0.8–1.3)**† |
0.05 (0.04–0.06) |
0.02 (0.01–0.02) |
50 (43–58)***††† |
0.004 (0.002–0.007)††† |
9 (4–25)††† |
| + |
15 |
6.1 (5.3–8.4) |
1.5 (1.0–2.5)† |
0.05 (0.03–0.05) |
0.02 (0.01–0.02) |
35 (29–40) |
0.005 (0.002–0.006)††† |
10 (5–16)† |
|
|
Values are medians and interquartile ranges for each group; n is the number of mice. Comparison between sham operation and ovariectomy (OVX): **P < 0.01; ***P < 0.001. Comparison between arthritic mice and their controls: †P < 0.05; †††P < 0.001. | |||||||||
Jochems et al. Arthritis Research & Therapy 2005 7:R837 doi:10.1186/ar1753 |
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