Table 1 |
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|
Serological markers of inflammation and histopathological findings were not significantly affected by ovariectomy |
||||||||
| Arthritis |
OVX |
No. of mice |
IgG (mg/ml) |
CII antibody (ng/ml) |
Interleukin-6 (pg/ml) |
Frequency of arthritis, day 45 (%) |
Arthritic score, day 45 |
Histopathology (score) |
|
|
||||||||
| - |
- |
10 |
10 (10–12) |
n.d |
62 (48–67) |
0 |
0 |
0 |
| + |
10 |
10 (7–15) |
n.d |
80 (42–111) |
0 |
0 |
0 |
|
| + |
- |
18 |
18 (15–23) |
4.6 (2.6–8.0) |
343 (214–755) |
100 |
8 (7–10)*** |
9.5 (7.0–11.5) |
| + |
15 |
18 (15–18) |
3.5 (2.3–4.6) |
371 (280–602) |
100 |
11 (10–12) |
11.0 (8.9–13.0) |
|
|
|
||||||||
|
Values are medians and interquartile ranges for each group. The maximum arthritic score was 12 points per mouse. ***P < 0.001 between sham-operated and ovariectomized arthritic mice. CII, type II collagen; n.d., not detectable; OVX, ovariectomy. |
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|
Jochems et al. Arthritis Research & Therapy 2005 7:R837 doi:10.1186/ar1753 |
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