Table 3

Comparison of the expression of selected genes in two groups of patients with rheumatoid arthritis^a

Candidate gene

Group I^b

Group II^b

Q (%)

P^c

A – Expressed at higher levels in group II than in group I

CASP9

-0.029 ± 0.018

0.020 ± 0.014

0.25

<0.001

PIG11

-0.025 ± 0.021

0.024 ± 0.017

0.25

<0.001

CTSG

-0.018 ± 0.024

0.031 ± 0.021

0.25

0.001

CSF2RB

-0.020 ± 0.024

0.019 ± 0.021

0.61

0.006

TNFRSF1A

-0.023 ± 0.029

0.015 ± 0.016

0.77

0.010

IL10RB

-0.021 ± 0.027

0.017 ± 0.021

0.90

0.012

B – Expressed at higher levels in group I than in group II

FN1

0.023 ± 0.018

-0.030 ± 0.019

0.25

<0.001

B2M

0.020 ± 0.023

-0.028 ± 0.022

0.25

0.001

SDC2

0.023 ± 0.024

-0.024 ± 0.021

0.25

0.001

CTSB

0.006 ± 0.019

-0.036 ± 0.026

0.84

0.002

STAT1

0.021 ± 0.031

-0.020 ± 0.014

1.19

0.008

ITGB2

0.021 ± 0.025

-0.018 ± 0.023

1.51

0.008

IFNGR2

0.019 ± 0.026

-0.016 ± 0.026

3.28

0.022

^aStatistical analysis on microarray data was performed using the significance analysis of microarrays (SAM) method (see Materials and methods). Q, which is the lowest false discovery rate, was considered significant at less than 5%. It is similar to the familiar P value, but adapted to the analysis of a large number of genes. ^bMeans ± standard deviations for the group, using log-transformed and median-centered microarray data. ^cValues calculated by t-test. P <0.05 was considered significant.

Tsubaki et al. Arthritis Research & Therapy 2005 7:R825   doi:10.1186/ar1751