|
Histological scores in patients with early (E) and long-standing (L) rheumatoid arthritis (RA) |
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| Group I |
Group II |
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|
|
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| Histological feature |
L-01 |
L-04 |
L-02 |
E-01 |
E-10 |
E-04 |
L-03 |
E-06 |
E-12 |
E-09 |
E-03 |
E-02 |
E-08 |
E-07 |
E-05 |
E-11 |
|
|
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| Proliferation of synovial cells |
3 |
2 |
1 |
1 |
1 |
2 |
2 |
2 |
2 |
2 |
1 |
1 |
2 |
1 |
2 |
1 |
| 1.80 ± 0.63 (1.67 ± 0.52) |
1.33 ± 0.52 |
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| Typical palisading |
3 |
3 |
3 |
2 |
2 |
2 |
2 |
1 |
2 |
3 |
1 |
1 |
2 |
2 |
2 |
0 |
| 2.30 ± 0.68*(2.00 ± 0.63) |
1.33 ± 0.82 |
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| Non-foreign-body giant cells |
2 |
3 |
3 |
1 |
2 |
1 |
1 |
1 |
2 |
1 |
1 |
3 |
1 |
2 |
0 |
0 |
| 1.70 ± 0.82 (1.33 ± 0.52) |
1.17 ± 0.48 |
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| Lymphoid cell infiltration |
3 |
1 |
3 |
0 |
2 |
1 |
2 |
1 |
1 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
| 1.60 ± 0.97† (1.17 ± 0.75*) |
0.00 ± 0.00 |
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| Plasma cell infiltration |
3 |
3 |
3 |
0 |
3 |
2 |
3 |
1 |
3 |
3 |
0 |
0 |
1 |
0 |
0 |
0 |
| 2.40 ± 1.08† (2.00 ± 1.27*) |
0.17 ± 0.41 |
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| Neovascularization |
2 |
2 |
2 |
2 |
2 |
2 |
3 |
2 |
2 |
3 |
3 |
3 |
2 |
2 |
1 |
3 |
| 2.20 ± 0.42 (2.17 ± 0.41) |
2.33 ± 0.82 |
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| Mesenchymoid transformation |
1 |
1 |
2 |
0 |
0 |
0 |
1 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
| 0.80 ± 1.03 (0.50 ± 1.23) |
0.00 ± 0.00 |
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| Fibrinoid necrosis |
1 |
3 |
2 |
0 |
0 |
0 |
1 |
0 |
1 |
2 |
0 |
0 |
1 |
0 |
1 |
0 |
| 1.00 ± 1.05 (0.50 ± 0.84) |
0.33 ± 0.52 |
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| Total |
18 |
18 |
19 |
6 |
12 |
10 |
15 |
8 |
13 |
19 |
6 |
8 |
9 |
7 |
6 |
4 |
| 13.80 ± 4.76† (11.33 ± 4.37*) |
6.67 ± 1.75 |
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|
The value in the upper row is the histological score of each case. More than 6 samples were taken from each patient for the feature studied. The value in the lower row is the mean ± standard deviation for the group. Values in parentheses (group I) are those for only the patients with early RA. †P <0.01, *P <0.05 versus group II on the Mann–Whitney test. ACR, American College of Rheumatology. | ||||||||||||||||
Tsubaki et al. Arthritis Research & Therapy 2005 7:R825 doi:10.1186/ar1751 |
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