Table 2

Comparisons between synovial fluid cytokineconcentrations in patients with early synovitis that develops into rheumatoid arthritis and other patient groups

Cytokine

Early RA versus all other early synovitis

Early RA versus established RA


P

Q

P

Q


IL-13

<0.00001

0.00002

0.00008

0.0004

EGF

<0.00001

0.00002

0.002

0.007

bFGF

<0.00001

0.00002

0.002

0.007

IL-4

<0.00001

0.00002

0.004

0.0097

IL-2

<0.00001

0.00002

0.004

0.0097

Eotaxin

0.00003

0.0002

NS

NS

IL-1

0.00003

0.0002

NS

NS

IL-17

0.00005

0.0003

0.002

0.007

IL-15

0.0001

0.0005

NS

NS

MIP-1β

0.0005

0.002

NS

NS

MIP-1α

0.0006

0.002

NS

NS

IL-12

0.002

0.006

NS

NS

GM-CSF

0.002

0.006

NS

NS

G-CSF

0.004

0.0097

NS

NS


Comparator groups were, first, patients with all other early synovitis (synovitis that develops into non-rheumatoid persistent synovitis plus non-crystal-related resolving synovitis plus crystal-related resolving synovitis) and, second, patients with established rheumatoid arthritis (RA). Groups were compared using the Wilcoxon rank sum test. The significance of the difference between groups is shown (P). The false discovery rate correction was used to correct for the multiple comparisons made. Results are reported as Q values, which represent the likelihood of obtaining a given P value by chance, given the multiple tests performed. For cytokines not shown there were no significant differences between groups (a 1% false discovery rate [Q < 0.01] was used as the threshold for statistical significance). bFGF, basic fibroblast growth factor; EGF, epidermal growth factor; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte–macrophage colony-stimulating factor; IL, interleukin; MIP, macrophage inflammatory protein; NS, not significant.

Raza et al. Arthritis Research & Therapy 2005 7:R784-R795   doi:10.1186/ar1733

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