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Open Access Highly Accessed Research article

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

Karim Raza*, Francesco Falciani, S John Curnow, Emma J Ross, Chi-Yeung Lee, Arne N Akbar, Janet M Lord, Caroline Gordon, Christopher D Buckley and Mike Salmon

Arthritis Research & Therapy 2005, 7:R784-R795  doi:10.1186/ar1733

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Special synovial reactivity becomes into Rheumatoid Arthritis or Rheumatoid Arthritis synovial reactivity is different from other arthritides?

Salvador Vale   (2005-05-10 22:28)  INDESALUD email

I have read with care the interesting article of Raza ET al. (1), about the characteristics of the synovial reactivity in Early Rheumatoid Arthritis (RA) and the different cytokines that characterize this reaction as compared with the synovial reactivity when arthritis is already a chronic process.

The authors conclude: The data presented herein suggest that the pathology of RA within the first few months after symptom onset is distinct from that of other early inflammatory arthritides and of established RA. These conclusions are justified by the findings described in the body of the manuscript.

Nevertheless, authors' conclusions includes: The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA. This statement suggests that when in some type of arthritide appears an exaggerated reactivity of T cells (and the special associated inflammatory cytoxines), this arthritide becomes chronic RA (see for example, the following proposal from the authors: The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA); in this sense, in the body of the article does not exist data to justify this affirmation.

An alternative explanation to these data would be that when an acute artritides corresponds to a RA etiology, behaves differently since their early stages (in T cells reactivity and the expressed cytokines) as compared to other arthritides with different etiology.

1.- Raza K, Falciani F, Curnow SJ et al. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin Arthritis Research & Therapy 2005, 7:R784-R795.

Competing interests

I have no competing interests

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