Table 2

Comparison of the overall mutational frequencies of V_H rearrangements obtained from individual peripheral CD19⁺ (CD27^- or CD27⁺) B cells of rheumatoid arthritis patient A before therapy and 7 months after first therapy

Before therapy

7 months after therapy

n

Mutations (n)

Total bp

Mutational frequency (%)

n

Mutations (n)

Total bp

Mutational frequency (%)

CD19⁺CD27^-

18

27

4,349

0.62

15

183

3,443

5.31*

CD19⁺CD27⁺

Not determined

22

477

5,745

8.30

* P < 0.0001 versus before therapy using chi-square test.

Rouzière et al. Arthritis Research & Therapy 2005 7:R714   doi:10.1186/ar1731