Arthritis Research & Therapy | Volume 7 Issue 4

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	Volume 7 Issue 4
	Comment
	Viewpoint The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation Ranjeny Thomas Arthritis Research & Therapy 2005, 7:170-173 (23 June 2005) Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Soluble RAGE: a hot new biomarker for the hot joint? Bernhard Moser, Barry I Hudson, Ann Schmidt Arthritis Research & Therapy 2005, 7:142-144 (3 June 2005) Abstract \| Full text \| PDF \| PubMed
	Commentary Histone deacetylases – a new target for suppression of cartilage degradation? John S Mort Arthritis Research & Therapy 2005, 7:155-156 (16 June 2005) Abstract \| Full text \| PDF \| PubMed
	Commentary Pathogenesis of rheumatoid arthritis: how early is early? Gary S Firestein Arthritis Research & Therapy 2005, 7:157-159 (17 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review
	Review The role of the complement and the FcγR system in the pathogenesis of arthritis Samuel Solomon, Daniela Kassahn, Harald Illges Arthritis Research & Therapy 2005, 7:129-135 (16 May 2005) Abstract \| Full text \| PDF \| PubMed
	Review Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B27 Sanna Vähämiko, Markus A Penttinen, Kaisa Granfors Arthritis Research & Therapy 2005, 7:136-141 (26 May 2005) Abstract \| Full text \| PDF \| PubMed
	Review Modeling human arthritic diseases in nonhuman primates Michel PM Vierboom, Margreet Jonker, Ronald E Bontrop, Bert 't Hart Arthritis Research & Therapy 2005, 7:145-154 (9 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis Gavin C Jones, Graham P Riley Arthritis Research & Therapy 2005, 7:160-169 (21 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research
	Research article Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody Anne-Sophie Rouzière, Christian Kneitz, Arumugam Palanichamy, Thomas Dörner, Hans-Peter Tony Arthritis Research & Therapy 2005, 7:R714-R724 (1 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Dynamic magnetic resonance of the wrist in psoriatic arthritis reveals imaging patterns similar to those of rheumatoid arthritis Marco A Cimmino, Massimiliano Parodi, Stefania Innocenti, Giulia Succio, Simone Banderali, Enzo Silvestri, Giacomo Garlaschi Arthritis Research & Therapy 2005, 7:R725-R731 (1 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration Christine Le Maitre, Anthony J Freemont, Judith Hoyland Arthritis Research & Therapy 2005, 7:R732-R745 (1 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy Takako Miyamae, David E Malehorn, Bonnie Lemster, Masaaki Mori, Tomoyuki Imagawa, Shumpei Yokota, William L Bigbee, Manda Welsh, Klaus Klarskov, Norihiro Nishomoto, Abbe N Vallejo, Raphael Hirsch Arthritis Research & Therapy 2005, 7:R746-R755 (4 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Chondrocytes, synoviocytes and dermal fibroblasts all express PH-20, a hyaluronidase active at neutral pH Hafida El Hajjaji, Ada Cole, Daniel-Henri Manicourt Arthritis Research & Therapy 2005, 7:R756-R768 (4 April 2005) Abstract \| Full text \| PDF \| PubMed
	Research article A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat James C Keith, Irma M Sainz, Irma Isordia-Salas, Robin A Pixley, Yelena Leathurby, Leo M Albert, Robert W Colman Arthritis Research & Therapy 2005, 7:R769-R776 (4 April 2005) Abstract \| Full text \| PDF \| PubMed
	Research article Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes Abdelhamid Liacini, Judith Sylvester, Wen Li, Muhammad Zafarullah Arthritis Research & Therapy 2005, 7:R777-R783 (4 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin Karim Raza, Francesco Falciani, S John Curnow, Emma J Ross, Chi-Yeung Lee, Arne N Akbar, Janet M Lord, Caroline Gordon, Christopher D Buckley, Mike Salmon Arthritis Research & Therapy 2005, 7:R784-R795 (7 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Patients with early arthritis who subsequently develop rheumatoid arthritis (RA) have a distinct but transient synovial fluid cytokine profile. This not only gives clues about the pathology of RA, but also has potential for use as a diagnostic tool.
	Research article Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score Daniel Aletaha, Valerie PK Nell, Tanja Stamm, Martin Uffmann, Stephan Pflugbeil, Klaus Machold, Josef S Smolen Arthritis Research & Therapy 2005, 7:R796-R806 (7 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation Julia J Inglis, Ahuva Nissim, Delphine M Lees, Stephen P Hunt, Yuti Chernajovsky, Bruce L Kidd Arthritis Research & Therapy 2005, 7:R807-R816 (12 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control Rille Pullerits, Maria Bokarewa, Leif Dahlberg, Andrej Tarkowski Arthritis Research & Therapy 2005, 7:R817-R824 (25 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens Takahito Tsubaki, Norimasa Arita, Takuma Kawakami, Takayuki Shiratsuchi, Haruyasu Yamamoto, Nobuo Takubo, Kazuhito Yamada, Sanpei Nakata, Sumiki Yamamoto, Masato Nose Arthritis Research & Therapy 2005, 7:R825-R836 (25 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation Caroline Jochems, Ulrika Islander, Malin Erlandsson, Margareta Verdrengh, Claes Ohlsson, Hans Carlsten Arthritis Research & Therapy 2005, 7:R837-R843 (27 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes Tanya R Da Sylva, Alison Connor, Yvonne Mburu, Edward Keystone, Gillian E Wu Arthritis Research & Therapy 2005, 7:R844-R851 (28 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comparison of synoviocyte mitochondrial DNA from rheumatoid arthritis (RA) and osteoarthritis patients has revealed a mutation frequency that is twice as high in RA patients. These mutations may contribute to the pathogenesis of RA.
	Research article Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis Allan A Young, Margaret M Smith, Susan M Smith, Martin A Cake, Peter Ghosh, Richard A Read, James Melrose, David H Sonnabend, Peter J Roughley, Christopher B Little Arthritis Research & Therapy 2005, 7:R852-R861 (12 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Reliability of computerized image analysis for the evaluation of serial synovial biopsies in randomized controlled trials in rheumatoid arthritis Jasper J Haringman, Marjolein Vinkenoog, Danielle M Gerlag, Tom JM Smeets, Aeilko H Zwinderman, Paul P Tak Arthritis Research & Therapy 2005, 7:R862-R867 (12 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis Philip Gierer, Saleh Ibrahim, Thomas Mittlmeier, Dirk Koczan, Steffen Moeller, Jürgen Landes, Georg Gradl, Brigitte Vollmar Arthritis Research & Therapy 2005, 7:R868-R876 (17 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Perforin deficiency attenuates collagen-induced arthritis Kristin Bauer, Annika Knipper, Hoang Tu-Rapp, Dirk Koczan, Hans-Jürgen Kreutzer, Horst Nizze, Eilhard Mix, Hans-Juergen Thiesen, Rikard Holmdahl, Saleh M Ibrahim Arthritis Research & Therapy 2005, 7:R877-R884 (20 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis Peter LEM van Lent, Karin CAM Nabbe, Arjen B Blom, Annet Sloetjes, Astrid EM Holthuysen, Jay Kolls, Fons AJ Van De Loo, Steven M Holland, Wim B Van Den Berg Arthritis Research & Therapy 2005, 7:R885-R895 (20 May 2005) Abstract \| Full text \| PDF \| PubMed
	Research article Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations Paola Margutti, Maurizio Sorice, Fabrizio Conti, Federica Delunardo, Mauro Racaniello, Cristiano Alessandri, Alessandra Siracusano, Rachele Riganò, Elisabetta Profumo, Guido Valesini, Elena Ortona Arthritis Research & Therapy 2005, 7:R896-R903 (20 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato, Kusuki Nishioka Arthritis Research & Therapy 2005, 7:R904-R914 (27 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central

	Volume 7 Issue 4
	Comment
	Viewpoint The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation Ranjeny Thomas Arthritis Research & Therapy 2005, 7:170-173 (23 June 2005) Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Soluble RAGE: a hot new biomarker for the hot joint? Bernhard Moser, Barry I Hudson, Ann Schmidt Arthritis Research & Therapy 2005, 7:142-144 (3 June 2005) Abstract \| Full text \| PDF \| PubMed
	Commentary Histone deacetylases – a new target for suppression of cartilage degradation? John S Mort Arthritis Research & Therapy 2005, 7:155-156 (16 June 2005) Abstract \| Full text \| PDF \| PubMed
	Commentary Pathogenesis of rheumatoid arthritis: how early is early? Gary S Firestein Arthritis Research & Therapy 2005, 7:157-159 (17 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review
	Review The role of the complement and the FcγR system in the pathogenesis of arthritis Samuel Solomon, Daniela Kassahn, Harald Illges Arthritis Research & Therapy 2005, 7:129-135 (16 May 2005) Abstract \| Full text \| PDF \| PubMed
	Review Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B27 Sanna Vähämiko, Markus A Penttinen, Kaisa Granfors Arthritis Research & Therapy 2005, 7:136-141 (26 May 2005) Abstract \| Full text \| PDF \| PubMed
	Review Modeling human arthritic diseases in nonhuman primates Michel PM Vierboom, Margreet Jonker, Ronald E Bontrop, Bert 't Hart Arthritis Research & Therapy 2005, 7:145-154 (9 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis Gavin C Jones, Graham P Riley Arthritis Research & Therapy 2005, 7:160-169 (21 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research
	Research article Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody Anne-Sophie Rouzière, Christian Kneitz, Arumugam Palanichamy, Thomas Dörner, Hans-Peter Tony Arthritis Research & Therapy 2005, 7:R714-R724 (1 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Dynamic magnetic resonance of the wrist in psoriatic arthritis reveals imaging patterns similar to those of rheumatoid arthritis Marco A Cimmino, Massimiliano Parodi, Stefania Innocenti, Giulia Succio, Simone Banderali, Enzo Silvestri, Giacomo Garlaschi Arthritis Research & Therapy 2005, 7:R725-R731 (1 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration Christine Le Maitre, Anthony J Freemont, Judith Hoyland Arthritis Research & Therapy 2005, 7:R732-R745 (1 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy Takako Miyamae, David E Malehorn, Bonnie Lemster, Masaaki Mori, Tomoyuki Imagawa, Shumpei Yokota, William L Bigbee, Manda Welsh, Klaus Klarskov, Norihiro Nishomoto, Abbe N Vallejo, Raphael Hirsch Arthritis Research & Therapy 2005, 7:R746-R755 (4 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Chondrocytes, synoviocytes and dermal fibroblasts all express PH-20, a hyaluronidase active at neutral pH Hafida El Hajjaji, Ada Cole, Daniel-Henri Manicourt Arthritis Research & Therapy 2005, 7:R756-R768 (4 April 2005) Abstract \| Full text \| PDF \| PubMed
	Research article A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat James C Keith, Irma M Sainz, Irma Isordia-Salas, Robin A Pixley, Yelena Leathurby, Leo M Albert, Robert W Colman Arthritis Research & Therapy 2005, 7:R769-R776 (4 April 2005) Abstract \| Full text \| PDF \| PubMed
	Research article Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes Abdelhamid Liacini, Judith Sylvester, Wen Li, Muhammad Zafarullah Arthritis Research & Therapy 2005, 7:R777-R783 (4 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin Karim Raza, Francesco Falciani, S John Curnow, Emma J Ross, Chi-Yeung Lee, Arne N Akbar, Janet M Lord, Caroline Gordon, Christopher D Buckley, Mike Salmon Arthritis Research & Therapy 2005, 7:R784-R795 (7 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Patients with early arthritis who subsequently develop rheumatoid arthritis (RA) have a distinct but transient synovial fluid cytokine profile. This not only gives clues about the pathology of RA, but also has potential for use as a diagnostic tool.
	Research article Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score Daniel Aletaha, Valerie PK Nell, Tanja Stamm, Martin Uffmann, Stephan Pflugbeil, Klaus Machold, Josef S Smolen Arthritis Research & Therapy 2005, 7:R796-R806 (7 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation Julia J Inglis, Ahuva Nissim, Delphine M Lees, Stephen P Hunt, Yuti Chernajovsky, Bruce L Kidd Arthritis Research & Therapy 2005, 7:R807-R816 (12 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control Rille Pullerits, Maria Bokarewa, Leif Dahlberg, Andrej Tarkowski Arthritis Research & Therapy 2005, 7:R817-R824 (25 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens Takahito Tsubaki, Norimasa Arita, Takuma Kawakami, Takayuki Shiratsuchi, Haruyasu Yamamoto, Nobuo Takubo, Kazuhito Yamada, Sanpei Nakata, Sumiki Yamamoto, Masato Nose Arthritis Research & Therapy 2005, 7:R825-R836 (25 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation Caroline Jochems, Ulrika Islander, Malin Erlandsson, Margareta Verdrengh, Claes Ohlsson, Hans Carlsten Arthritis Research & Therapy 2005, 7:R837-R843 (27 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes Tanya R Da Sylva, Alison Connor, Yvonne Mburu, Edward Keystone, Gillian E Wu Arthritis Research & Therapy 2005, 7:R844-R851 (28 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comparison of synoviocyte mitochondrial DNA from rheumatoid arthritis (RA) and osteoarthritis patients has revealed a mutation frequency that is twice as high in RA patients. These mutations may contribute to the pathogenesis of RA.
	Research article Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis Allan A Young, Margaret M Smith, Susan M Smith, Martin A Cake, Peter Ghosh, Richard A Read, James Melrose, David H Sonnabend, Peter J Roughley, Christopher B Little Arthritis Research & Therapy 2005, 7:R852-R861 (12 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Reliability of computerized image analysis for the evaluation of serial synovial biopsies in randomized controlled trials in rheumatoid arthritis Jasper J Haringman, Marjolein Vinkenoog, Danielle M Gerlag, Tom JM Smeets, Aeilko H Zwinderman, Paul P Tak Arthritis Research & Therapy 2005, 7:R862-R867 (12 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis Philip Gierer, Saleh Ibrahim, Thomas Mittlmeier, Dirk Koczan, Steffen Moeller, Jürgen Landes, Georg Gradl, Brigitte Vollmar Arthritis Research & Therapy 2005, 7:R868-R876 (17 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Perforin deficiency attenuates collagen-induced arthritis Kristin Bauer, Annika Knipper, Hoang Tu-Rapp, Dirk Koczan, Hans-Jürgen Kreutzer, Horst Nizze, Eilhard Mix, Hans-Juergen Thiesen, Rikard Holmdahl, Saleh M Ibrahim Arthritis Research & Therapy 2005, 7:R877-R884 (20 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis Peter LEM van Lent, Karin CAM Nabbe, Arjen B Blom, Annet Sloetjes, Astrid EM Holthuysen, Jay Kolls, Fons AJ Van De Loo, Steven M Holland, Wim B Van Den Berg Arthritis Research & Therapy 2005, 7:R885-R895 (20 May 2005) Abstract \| Full text \| PDF \| PubMed
	Research article Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations Paola Margutti, Maurizio Sorice, Fabrizio Conti, Federica Delunardo, Mauro Racaniello, Cristiano Alessandri, Alessandra Siracusano, Rachele Riganò, Elisabetta Profumo, Guido Valesini, Elena Ortona Arthritis Research & Therapy 2005, 7:R896-R903 (20 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato, Kusuki Nishioka Arthritis Research & Therapy 2005, 7:R904-R914 (27 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central

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Volume 7 Issue 4

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