Time course of knee joint swelling. Joint swelling (difference between the bilateral diameter of the right knee and the left knee) in untreated antigen-induced arthritis (AIA) rats and in hyaluronic acid (HA)-treated AIA rats. V, end of the short-term test (day 8) and end of the long-term test (day 29). The arrows indicate the days of intra-articular injection of HA (days 1, 8, 15, and 22). In the short-term test there was no significant difference between HA-treated rats and untreated AIA rats. In the long-term test HA-treated AIA rats showed significantly reduced values on day 15 (* P < 0.05). On day 29 there were no longer differences between the two groups; if at all, the swelling in the HA-treated group was somewhat higher than in untreated AIA group.
Roth et al. Arthritis Research & Therapy 2005 7:R677-R686 doi:10.1186/ar1725