Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis
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* Corresponding author: Andreas Roth ajroth@gmx.de
Arthritis Research & Therapy 2005, 7:R677-R686 doi:10.1186/ar1725
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Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells Kelly S Santangelo, Amanda L Johnson, Amy S Ruppert, Alicia L Bertone Arthritis Research & Therapy 2007, 9:R1 (10 January 2007) In vitro studies show hyaluronan (HA) has an anti-inflammatory effect regardless of its molecular weight, providing further evidence HA is a potentially valuable treatment option for inflammatory synovitis and rheumatoid arthritis.
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