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Other dermatological events in patients with rheumatoid arthritis (RA) given TNF-α-blocking therapy |
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| Patient no. |
Age (yr) |
Sex |
Diagnosis |
Druga |
Active treatment |
Event |
Clinical description |
Localization |
Time to event |
Biopsy |
Comedicationb |
Permanent withdrawal anti-TNF-α |
Therapy |
Course |
|
|
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| 1 |
56 |
f |
RA |
A |
Yes |
Lymphomatoid papulosis-like eruption |
Macular erythematosquamous lesions |
Lower arms, upper legs and trunk |
2.6 |
Yes |
naproxen |
No |
None |
Recovery |
| 2 |
53 |
f |
RA |
A |
Yes |
Rosacea |
Diffuse erythema, scaling, telangiectasias |
Head and face |
1.9 |
Yes |
prednisolone, captopril, indomethacin, midazolam |
No |
Topical |
Persisting |
| 3 |
74 |
f |
RA |
E |
Yes |
Pruritus |
Itch |
Trunk |
2.5 |
No |
None |
No |
Topical |
Unknown |
| 4 |
61 |
f |
RA |
I |
No |
Ecchymoses |
Ecchymoses |
Hands and feet |
25.9 |
No |
AZA, prednisolone |
No |
Topical |
Partial recovery |
| 5 |
58 |
f |
RA |
I |
Yes |
Drug-induced systemic lupus emythematosus |
Discoid erythematous lesions, aphthous lesions, ANA positive, anti-ds-DNA positive |
Hands, face, scalp |
20.0 |
No |
MTX |
Yes |
Topical and systemic |
Recovery, no rechallenge |
| 6 |
68 |
m |
RA |
I |
Yes |
Transient swelling of unknown cause |
Transient swelling 2 × 3 cm |
Scalp |
20.0 |
No |
MTX, folic acid, naproxen |
No |
None |
Recovery |
| 7 |
52 |
f |
RA |
L |
Yes |
Dermatomyositis |
Livid erythema, raised CPK, decreased proximal muscular strength |
Inner upper arms and legs |
2.5 |
Yes |
None |
Yes |
None |
Recovery |
| 8 |
53 |
m |
RA |
L |
No |
Erythema nodosum |
Painful erythematous nodules |
Lower legs |
7.4 |
Yes |
AZA, naproxen, paracetamol |
No |
Topical |
Partial recovery |
|
aA, adalimumab; I, infliximab; E, etanercept; L, lenercept. bMTX, methotrexate; AZA, azathioprine. CPK, creatinine phosphokinase; f, female, m, male. | ||||||||||||||
Flendrie et al. Arthritis Research & Therapy 2005 7:R666 doi:10.1186/ar1724 |
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