Table 4

Drug-related skin eruptions in patients with rheumatoid arthritis (RA) given TNF-α-blocking therapy
Patient no.
 Age (yr)
 Sex
 Druga
 Route
 Type of eruption
 Clinical description
 Localization
 Time to event (mo)
 Biopsy
 Comedicationb
 Therapy
 Rechallenge
 Permanent withdrawal of anti-TNF-α
 Course
1
 62
 f
 A
 i.v.
 Eczematous
 Erythematosquamous plaques and papules
 Neck/ axillary/ legs
 4.5
 Yes
 naproxen
 Local
 positive
 No
 Recurring
2
 71
 m
 A
 i.v.
 Exanthematous lichenoid
 Maculopapular exanthema
 Generalized
 0.7
 Yes
 prednisolone, naproxen, paracetamol
 Local
 positive
 Yes
 Recovery
3
 77
 m
 E
 s.c.
 Exanthematous
 Macular exanthema
 Generalized
 6.8
 Yes
 prednisolone, naproxen, omeprazole
 Local
 positive
 No
 Recurring
4
 67
 m
 E
 s.c.
 Lichenoid
 Macular exanthema, purpura
 Generalized
 1.5
 Yes
 diclofenac, omeprazole, triamterene, furosemide, candesartan
 Topical, systemic
 No
 Yes
 Recovery
5
 69
 f
 I
 i.v.
 Eczematous
 Erythematous plaque
 Right cheek
 0.1
 Yes
 MTX, pantoprazole, atenolol, calcium, hydrochlorothiazide
 Topical
 positive
 No
 Recurring
6
 88
 f
 I
 i.v.
 Eczematous urticarial
 Erythematosquamous macula, purpura
 Lower arms/legs
 3.9
 Yes
 leflunomide, carbasalate calcium, omeprazole, furosemide, simvastatin, paracetamol
 Topical
 No
 Yes
 Recovery
7
 68
 f
 I
 i.v.
 Eczematous urticarial
 Erythematosquamous plaques, urticaria, excoriations, lichenification, purpura
 Generalized
 10.3
 No
 AZA, furosemide, oxazepam, enalapril, spironolactone, metoprolol, flixotide, formoterol
 Topical, systemic
 negative
 No
 Recovery
8
 60
 f
 I
 i.v.
 Exanthematous
 Stippled exanthema
 Generalized
 0.5
 Yes
 naproxen, omeprazole
 Topical
 No
 Yes
 Recovery
9
 53
 f
 I
 i.v.
 Exanthematous
 Exanthema
 Upper arms/legs
 0.2
 No
 indomethacin
 Topical
 positive
 No
 Recurring
10
 73
 f
 I
 i.v.
 Exanthematous, with purpura
 Exanthema, purpura
 Lower legs
 18.8
 No
 MTX, folic acid, prednisolone, morphine, loperamide, latanoprost
 Topical
 No
 Yes
 Recovery
11
 70
 f
 I
 i.v.
 Exanthematous urticarial
 Exanthema, urticaria
 Arms/ trunk
 16.6
 Yes
 leflunomide
 None
 positive
 No
 Recurring
12
 35
 f
 I
 i.v.
 Exanthematous urticarial, with purpura
 Macular exanthema, uricaria, purpura
 Trunk/ axillary/ groins
 1.9
 Yes
 none
 Topical
 -
 Yes
 Recovery
13
 58
 f
 I
 i.v.
 Lichenoid
 Erythema, hyperpigmentation, atrophy
 Upper legs
 15.5
 Yes
 leflunomide, meloxicam, metoclopramide, acenocoumarol, digoxin
 None
 No
 Yes
 Recovery
14
 58
 f
 L
 i.v.
 Exanthematous
 Papular exanthema
 Generalized
 0.4
 Yes
 none
 Topical
 positive
 No
 Recurring
15
 68
 m
 L
 i.v.
 Exanthematous lichenoid
 Maculopapular exanthema
 Generalized
 1.7
 Yes
 prednisolone, paracetamol
 Topical
 negative
 No
 Recovery

Events numbers 5 and 11 occurred in the same patient, as did events numbers 2, 3, and 15. aA, adalimumab; Age = age ar event; I, infliximab; E, etanercept; L, lenercept. bMTX, methotrexate; AZA, azathioprine. f, female; i.v., intravenous; m, male; s.c., subcutaneous.

Flendrie et al. Arthritis Research & Therapy 2005 7:R666   doi:10.1186/ar1724