Table 2

Dermatological events in patients with rheumatoid arthritis (RA) given TNF-α-blocking therapy

Nature of event

Events

Time to event (months)

Events during treatment

Major events

Histology

DMARDsb

Prednisoloneb

Permanent withdrawal of anti-TNF-αc


No. (%)

Mediana

Range

No. (%)

No. (%)

No. (%)

No. (%)

No. (%)

No. (%)


Infection

33 (25.8)

9.1

1.1–61.1

24 (73)

0

5 (15)

20 (61)

21 (64)

4 (12)

Eczema

20 (15.6)

7.1

0.2–49.9

16 (80)

1 (5)

4 (20)

8 (40)

7 (35)

3 (15)

Drug-related eruption

15 (11.7)

1.9

0.1–18.8

15 (100)

1 (7)

12 (80)

6 (40)

6 (40)

7 47)

Ulcers

9 (7.0)

13.6

0.3–52.5

3 (33)

1 (11)

2 (22)

7 (78)

4 (44)

1 (11)

Skin tumor, benign

7 (5.5)

12.9

2.0–18.1

7 (100)

0

2 (29)

5 (71)

4 (57)

0

Skin tumor, malignant

5 (3.9)

4.5

1.1–38.0

4 (80)

0

5 (100)

2 (40)

2 (40)

1 (20)

Xerosis cutis

6 (4.7)

8.9

4.2–26.3

6 (100)

0

1 (16)

4 (67)

1 (17)

1 (17)

Vasculitis

5 (3.9)

12.0

1.5–49.9

4 (80)

0

4 (80)

3 (60)

5 (100)

1 (20)

Actinic keratosis

5 (3.9)

26.3

4.5–112.9

2 (40)

0

3 (60)

5 (100)

2 (40)

0

CVI/varices

4 (3.0)

24.0

1.7–33.6

3 (75)

0

0

3 (75)

2 (50)

0

Psoriasis/psoriasiform

3 (2.3)

15.5

8.4–50.1

3 (100)

0

3 (100)

0

2 (67)

1 (33)

Edema

3 (2.2)

8.2

4.0–39.6

2 (67)

0

1 (33)

1 (33)

1 (33)

0

Stasis dermatitis

3 (2.2)

17.5

14.6–42.1

3 (100)

0

1 (33)

1 (33)

1 (33)

0

Seborrheic dermatitis

2 (1.5)

0.4, 19.8

2 (100)

0

0

0

0

0

Other event

8 (6.0)

5.0

1.9–25.9

6 (75)

0

4 (50)

4 (50)

2 (25)

2 (25)

Total

128 (100)

9.1

0.1–112.9

100 (78)

3 (2)

47 (37)

69 (54)

60 (47)

21 (16)


aMedian and range given for three cases or more; individual data given for two cases or fewer. bNumber of patients with concomitant DMARDs and prednisolone at the time of event. cPermanent discontinuation of TNF-α-blocking therapy because of the event. DMARD, disease-modifying anti-rheumatic drug; TNF, tumor necrosis factor.

Flendrie et al. Arthritis Research & Therapy 2005 7:R666-R676   doi:10.1186/ar1724

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