Table 3

Discontinuations of treatment in arthritis because of lack of efficacy or adverse events

Lack-of-efficacy discontinuations

Adverse-event discontinuations


Duration (weeks)

Treatment

Dose (mg/day)

Number of events

Total number

Discontinuations, % (95% CI)

Number of events

Total number

Discontinuations, % (95% CI)


2–6

Placebo

339

1,925

17.6 (15.8–19.4)

97

1,925

5.0 (4.0–6.0)

Celecoxib

<100

42

253

16.6 (12.1–21.1)

8

253

3.2 (1.0–5.4)

Celecoxib

100

No data

No data

Celecoxib

200

203

4,190

4.8 (4.2–5.4)

223

4,190

5.3 (4.7–5.9)

Celecoxib

400

12

155

7.7 (3.6–11.8)

5

155

3.2 (0.5–5.9)

Celecoxib

800

15

180

8.3 (4.2–12.4)

14

180

7.8 (3.9–11.7)

Paracetamol

4,000

55

502

11.0 (8.3–13.7)

27

502

5.4 (3.4–7.4)

Rofecoxib

25

19

1,191

1.6 (0.8–2.4)

77

1,191

6.5 (5.1–7.9)

Naproxen

1,000

5

395

1.3 (0.1–2.5)

31

395

7.8 (5.3–10.3)

Diclofenac

100/150

13

540

2.4 (1.0–3.8)

51

540

9.4 (6.9–11.9)

12

Placebo

521

1,135

45.9 (43.0–48.8)

70

1,135

6.2 (4.8–7.6)

Celecoxib

100

145

692

21 (18.1–23.9)

52

692

7.5 (5.5–9.5)

Celecoxib

200

571

6,094

9.4 (8.6–10.2)

488

6,094

8.0 (7.4–8.6)

Celecoxib

400

492

6,166

8.0 (7.4–8.6)

590

6,166

9.6 (8.8–10.4)

Celecoxib

800

128

435

29.4 (25.1–33.7)

28

435

6.4 (4.0–8.8)

Paracetamol

4,000

No data

No data

Rofecoxib

25

1

132

0.8 (0.0–2.4)

13

132

9.8 (4.7–14.9)

Naproxen

1,000

374

2,399

15.6 (14.2–17.0)

316

2,399

13.2 (11.8–14.6)

Diclofenac

100/150

120

4,311

2.8 (2.2–3.4)

338

4,311

7.8 (7.0–8.6)

Ibuprofen

2,400

14

345

4.1 (1.9–6.3)

37

345

10.7 (7.4–14)

24+

Placebo

No data

No data

Celecoxib

100

No data

No data

Celecoxib

200

No data

No data

Celecoxib

400

26

326

8.0 (5.1–10.9)

34

326

10.4 (7.1–13.7)

Celecoxib

800

691

3,987

17.3 (16.1–18.5)

892

3,987

22.4 (21–23.8)

Paracetamol

4,000

No data

No data

Rofecoxib

25

No data

No data

Naproxen

1,000

No data

No data

Diclofenac

100/150

331

2,325

14.2 (12.8–15.6)

593

2,325

25.5 (23.7–27.3)

Ibuprofen

2,400

456

1,985

23.0 (21.2–24.8)

456

1,985

23.0 (21.2–24.8)


CI, confidence interval.

Moore et al. Arthritis Research & Therapy 2005 7:R644-R665   doi:10.1186/ar1704

Open Data