Table 3

Spearman correlations among biomarkers and potential cardiovascular risk factors

Cardiovascular risk factor

VCAM-1 (pg/ml)

ICAM-1 (pg/ml)

ELAM-1 (pg/ml)


Demographic

Age (years)

0.279

0.149

0.148

Lifestyle

Smoking (cigarettes/day)

0.209

0.253

0.062

Alcohol (units/week)

0.209

0.112

-0.072

Exercise (hours/week)

0.034

0.085

-0.055

Systemic inflammation

hs-CRP (mg/l)

0.289

0.189

0.217

ESR (mm/hour)

0.217

0.175

0.195

Disease duration (years)

0.138

0.069

0.079

Disease severity

Radiographic score

0.157

-0.012

0.092

Rheumatoid factor (IU/ml)

0.319**

0.363**

0.290

Cytokines

TNF-α (pg/ml)

0.107

0.204

0.019

IL-1 (pg/ml)

-0.123

-0.030

-0.120

IL-6 (pg/ml)

0.248

0.298*

0.359**

Drug therapy

Current prednisone dose (mg/day)

0.156

0.152

0.279

Cumulative prednisone dose (mg)

0.042

0.008

0.071

Cumulative pulsed MP (mg)

-0.051

-0.155

-0.096

Metabolic syndrome

Waist circumference (cm)

0.036

0.249

0.127

SBP (mmHg)

0.159

0.011

0.019

DBP (mmHg)

-0.042

-0.073

-0.097

HDL-cholesterol (mmol/l)

-0.093

-0.103

-0.091

Triglycerides (mmol/l)

0.186

0.181

0.079

QUICKI

-0.088

-0.035

-0.019

Uric acid (mmol/l)

0.208

0.271

0.260

Others

Haemoglobin (g/dl)

-0.139

-0.130

-0.093

Leucocytes (× 106/l)

-0.017

-0.096

0.199

Polymorphonuclear cells (×106/l)

0.041

-0.092

0.212

Platelets (109/l)

-0.025

-0.142

0.104

Homocysteine (μmol/l)

0.124

0.236

0.277

Thyrotropin (μIU/ml)

-0.132

-0.007

0.020

LDL-cholesterol (mmol/l)

-0.139

-0.078

0.175

Apolipoprotein(a) (mg/l)

0.097

0.004

0.063

GFR (ml/min)

-0.285*

-0.144

-0.121

Urinary albumin/creatinine (mg/mmol)

-0.182

-0.163

-0.031


DBP, diastolic blood pressure; ELAM, endothelial leukocyte adhesion molecule; ESR, erythrocyte sedimentation rate; GFR, glomerular filtration rate; HDL, high-density lipoprotein; hs-CRP, high-sensitivity C-reactive protein; ICAM, intercellular adhesion molecule; IL, interleukin; LDL, low-density lipoprotein; MP, methylprednisolone; QUICKI, Quantitative Insulin Sensitivity Check Index; SBP, systolic blood pressure; TNF, tumour necrosis factor; VCAM, vascular adhesion molecule. *P ≤ 0.01; **P < 0.006.

Dessein et al. Arthritis Research & Therapy 2005 7:R634-R643   doi:10.1186/ar1717

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