Table 2

Biomarkers of endothelial dysfunction in rheumatoid arthritis patients and control individuals

Marker

Controls

Patients

Unadjusted

P (multivariable adjusted)


Model 1a

Model 2b

Model 3c

Model 4d


VCAM-1 (pg/ml)

506 (253–1067)

747 (391–2077)

<0.0001

<0.0001

<0.0001

<0.0001

0.08

ICAM-1 (pg/ml)

231 (82–857)

366 (135–993)

<0.0001

0.0002

<0.0001

0.0005

0.08

ELAM-1 (pg/ml)

48 (7–178)

58 (12–149)

<0.0001

0.02

0.02

0.7

0.08


Results are expressed as median (range). Unadjusted comparisons were done using the Mann–Whitney U-test and adjustments for potentially explanatory variables were made using logistic regression models. aAdjusted for disease-modifying antirheumatic drug and prednisone use. bAdjusted for traditional risk factors (age; sex; race; smoking, alcohol and exercising status; diabetes; waist; systolic blood pressure; total cholesterol; high-density lipoprotein cholesterol; triglycerides). cAdjusted for nontraditional risk factors (high sensitivity C-reactive protein, interleukin IL-1, IL-6 and tumour necrosis factor-α). dAdjusted for traditional and nontraditional risk factors. ELAM, endothelial leukocyte adhesion molecule; ICAM, intercellular adhesion molecule; VCAM, vascular adhesion molecule.

Dessein et al. Arthritis Research & Therapy 2005 7:R634-R643   doi:10.1186/ar1717

Open Data