Expression of heme oxygenase (HO)-1 protein in PBMCs, determined using anti-HO-1 monoclonal antibody. (a) Untreated peripheral blood mononuclear cells (PBMCs) from a healthy control. (b) 100 μM hemin-treated PBMCs from a healthy control. (c) PBMCs from a patient with active adult-onset Still's disease (ASD) complicated by hemophagocytic syndrome (HPS). HO-1-expressing monocytes (stained red) were found in (b) and (c). Original magnification × 400.
Kirino et al. Arthritis Research & Therapy 2005 7:R616-R624 doi:10.1186/ar1721