Serum heme oxygenase (HO)-1 and ferritin in hemophagocytic syndrome (HPS) and adult-onset Still's disease (ASD). (a) Serum HO-1 levels of HPS patients (open circles) and ASD patients (filled circles) before and after remission. *P = 0.0078, as determined by the Wilcoxon signed-rank test. (b) Clinical course of ASD in a 34-year-old man. (c) Clinical course in a 45-year-old woman with HPS and systemic lupus erythematosus. 'Pulse' represents intravenous infusion of methylprednisolone at 1,000 mg/day for 3 days. ALT, alanine aminotransferase; CRP, C-reactive protein.
Kirino et al. Arthritis Research & Therapy 2005 7:R616-R624 doi:10.1186/ar1721