Serum heme oxygenase-1 in patients with hemophagocytic syndrome or adult-onset Still's disease. Also studied were normal controls (NC) and people with other rheumatic diseases including rheumatoid arthritis (RA) (n = 30), systemic lupus erythematosus (SLE) (n = 18), dermatomyositis/polymyositis (DM/PM) (n = 9), and Behçet's disease (BD) (n = 16). Filled circles and open circles represent patients with active and inactive disease, respectively. *P < 0.0001, **P = 0.0001, §P = 0.001, †P = 0.0007, ‡P = 0.003, as determined by the nonpaired Mann–Whitney U test. ASD, adult-onset Still's disease; HO-1, heme oxygenase 1; HPS, hemophagocytic syndrome.
Kirino et al. Arthritis Research & Therapy 2005 7:R616 doi:10.1186/ar1721