Table 3

Autoantibodies as prognostic markers of poor outcomes

Autoantibody

Measure

Outcomes at 30 months


Persistence

RA criteria

Severity


RF

Sensitivity

47.2

57.1

55.4

Specificity

91.7

62.8

63.0

Positive LR

5.69

1.53

1.50

Anti-Sa

Sensitivity

34.4

39.3

44.6

Specificity

95.8

72.7

79.3

Positive LR

8.26

1.44

2.16

Anti-CCP

Sensitivity

39.2

39.3

42.9

Specificity

91.7

66.9

70.7

Positive LR

4.70

1.19

1.46


Combinations of antibodies (rheumatoid factor (RF) and/or anti-Sa and/or anti-cyclic citrullinated peptide (anti-CCP)) are not shown, because none brought any improvement over the detection of anti-Sa alone. LR, likelihood ratio; RA, rheumatoid arthritis.

Boire et al. Arthritis Research & Therapy 2005 7:R592-R603   doi:10.1186/ar1719

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