Table 4

Comparison of histological markers between SpA (PsA + AS + USpA) synovium and RA synovium

Marker

SpA (n = 50)

RA (n = 52)

P


Lining layer thickness

1.0 (1.0–2.5)

2.0 (0–3.0)

0.006

Vascularity

2.0 (1.0–3.0)

1.5 (1.0–3.0)

<0.001

Cellular infiltration

1.5 (0–3.0)

2.0 (0–3.0)

0.120

Lymphoid follicles

0 (0–3.0)

0 (0–3.0)

0.232

Plasma cells

0.5 (0–3.0)

0.5 (0–3.0)

0.497

Polymorphonuclear cells

0 (0–3.0)

0 (0–2.5)

0.008

CD3

1.5 (0–3.0)

2.0 (0–3.0)

0.152

CD4

1.0 (0–3.0)

1.0 (0–3.0)

0.192

CD8

1.0 (0–3.0)

1.5 (0–3.0)

0.737

CD20

1.0 (0–3.0)

2.0 (0–3.0)

0.231

CD38

1.5 (0–3.0)

2.0 (0–3.0)

0.060

CD138

1.0 (0–3.0)

2.0 (0–3.0)

0.447

CD68 lining

1.0 (0–3.0)

1.0 (0–3.0)

0.631

CD68 sublining

1.5 (0–3.0)

1.5 (0.5–3.0)

0.957

CD163 lining

2.0 (0–3.0)

1.5 (0–3.0)

0.033

CD163 sublining

1.5 (0–3.0)

1.0 (0–2.5)

0.031

CD1a

0 (0–3.0)

1.0 (0–3.0)

0.121

CD83

0 (0–1.0)

0 (0–3.0)

0.006

CD146

2.0 (0–3.0)

0 (0–3.0)

0.075

αVβ3 lining

1.0 (0–3.0)

1.0 (0–3.0)

0.397

αVβ3 sublining

1.0 (0–3.0)

1.0 (0–3.0)

0.306

E-selectin blood vessels

1.0 (0–3.0)

1.5 (0–3.0)

0.760

ICAM-1 lining

3.0 (1.0–3.0)

2.5 (0–3.0)

0.025

ICAM-1 sublining

2.0 (0–3.0)

2.0 (0–3.0)

0.654

ICAM-1 blood vessels

2.5 (0.5–3.0)

2.5 (0–3.0)

0.652

VCAM-1 lining

3.0 (0–3.0)

3.0 (0–3.0)

0.077

VCAM-1 sublining

1.5 (0–3.0)

1.5 (0–3.0)

0.473

VCAM-1 blood vessels

1.0 (0–3.0)

1.5 (0–3.0)

0.997

Intracellular citrullinated proteins

0%

44%

<0.001

Mab-12A

0%

46%

<0.001


The Mann–Whitney U-test was used to evaluate markers scored semiquantitatively, and the χ2 test was used to evaluate markers scored as present or absent. Results are expressed as median (range), and markers evaluated as present or absent are expressed as percentage of positive results. P < 0.05 was considered statistically significant. AS, ankylosing spondylitis; ICAM, intercellular adhesion molecule; PsA, psoriatic arthritis; RA, rheumatoid arthritis; USpA, undifferentiated spondyloarthropathy; VCAM, vascular cell adhesion molecule.

Kruithof et al. Arthritis Research & Therapy 2005 7:R569-R580   doi:10.1186/ar1698

Open Data