The three-dimensional poly(lactic-glycolic acid) (3D-PLGA) scaffold. The micropore side (cell seeding side) (a) and a cross section (b) of the scaffold. Schematic illustration of cell seeding (left) and scanning electron photomicrograph of cross section of cells seeded in the 3D-PLGA scaffold (right) (c). The cells lie in a uniform array at the palisades, similar to hyaline cartilage. Gross appearance of a cartilage defect in the patella groove implanted with a complex between adherent bone marrow cells and 3D-PLGA scaffold (d). The arrows indicate cell/PLGA scaffold.
Hattori et al. Arthritis Research & Therapy 2005 7:R552 doi:10.1186/ar1710