Table 3

Signs of systemic lupus erythematosus (SLE) in 12 patients under anti-tumour necrosis factor alpha treatment

Sign of SLE

Number of patients


Skin (≥ 1 SLE skin criteria)

11

General (fever, weight loss, asthenia)

9

Musculoskeletal (arthritis, myositis, myalgias)

10 (6 arthritis, 3 myositis, 1 myalgia)

Serositis, lung, neuritis, phlebitis; haematological abnormalities, elevated muscle enzymes

3, 1, 1 and 1, respectively; 12 and 3, respectively

Antibody testing

Positive for ANA (>1/160)

12

Positive for anti-dsDNA antibodies (>40 UI)

11

Positive anti-ENA, anti-histone, anti-cardiolipid

5, 2 and 6, respectively

Recovery

After treatment withdrawn (with/without steroids)

12 (4 and 8)

Delay in recovery (median and range)

8 weeks (3–16 weeks)


Ten females, two males; nine patients treated with infliximab and three patients treated with etanercept. ANA, antinuclear antibodies; dsDNA, double-strand DNA; ENA, positive anti-extractable nuclear antigensantibodies.

De Bandt et al. Arthritis Research & Therapy 2005 7:R545-R551   doi:10.1186/ar1715

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