Table 2

General presentation of the 12 patients with 'complete lupus'

Patient

Before anti-TNF alpha treatment

During onset of symptoms


Disease

Autoantibody

Clinical signs of lupus

Treatment

Duration of treatment (months)

Clinical signs of lupusa

Biological signs of lupus


1

RA, RF+, erosive

None

None

INF

27

General, skin, serositis, lung

ANA+, dsDNA+, ACL+, leucopenia, thrombopenia, ENA+

2

RA, RF+, erosive

ANA+, Ro+

None

INF

4

General, skin (3), arthritis

ANA+, dsDNA+, histone +

3

RA, RF+, erosive

ANA+, Ro+

None

INF

2

Skin, myalgias, arthritis

ANA+, dsDNA+, ENA+,

4

RA, RF-, erosive

None

None

ETA

4

General, skin (2), myositis

ANA+, dsDNA+, ACL+, low C4, ENA+

5

RA, RF+, erosive

None

None

INF

4

Skin (3), myositis, arthritis, pericarditis

ANA+, dsDNA+, ACL+, CPK, lymphopenia

6

RA, RF+, erosive

ANA+, dsDNA+ limit value

None

ETA

5

General, skin

ANA+, dsDNA+, thrombopenia, leucopenia

7

RA, RF+, erosive

None

None

INF

10

General, serositis, myositis

ANA+, dsDNA+, ACL+, leucopenia, thrombopenia, CPK,

8

RA, RF+

None

None

ETA

2

Phlebitis, skin

ANA+, dsDNA+, leucopenia, ACL+, thrombopenia

9

Psoriatic arthritis

None

None

INF

14

General, skin, neurological

ANA+, dsDNA+

10

RA, RF+, erosive

None

None

INF

16

General, Skin, arthritis

ANA+, dsDNA+

11

RA, RF+, erosive

None

None

INF

12

General, skin (3), arthritis, myositis

ANA+, dsDNA+, ENA+, CPK

12

RA, RF+, erosive

None

None

INF

10

General, skin, arthritis

ANA+, dsDNA+, CPK, ENA+, ACL+, low C4, histone+, leucopenia, lymphopenia, Coombs test+


ACL, positive anticardiolipin antibodies; ANA, antinuclear antibodies; CPK, creatin phospokinase or muscle enyme, elevated muscle enzymes; dsDNA, double-strand DNA; ENA, positive anti-extractable nuclear antigens antibodies; ETA, etanercept; general, general manifestations (fever, weight loss, asthenia); histone, positive anti-histone antibodies; INF, infliximab; RA, rheumatoid arthritis; RF, rheumatoid factor; TNF, tumour necrosis factor; +, positive; -, negative.

aThe skin manifestations were as follows (number in parentheses indicates number of skin manifestations observed in one patient): maculo papular rash observed in six patients, butterfly rash observed in five patients, alopecia present in one patient, photosensitivity observed in five patients, purpuric lesions observed in two patients. One patient had no skin manifestations, seven patients had one sign, one patient had two different signs, and three patients had three skin manifestations.

De Bandt et al. Arthritis Research & Therapy 2005 7:R545-R551   doi:10.1186/ar1715

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