Table 4

Concentrations of inflammatory mediators in synovial fluid and plasma from arthritic patients (n = 11)

Mediator

Concentration

P


Synovial fluid

Plasma


MCP-1 (pg/ml)

134 (36–522)

34 (15–62)

0.008

sICAM-1 (ng/ml)

706 (226–1,085)

871 (657–1,691)

0.006

IL-8 (pg/ml)

614 (<50–24,630)

<50

0.002

IL-6 (pg/ml)

13,897 (35–43,131)

11 (0–57)

0.002

VEGF (pg/ml)

1,604 (528–2,506)

23 (<5–69)

0.002

RANTES (pg/ml)

7 (<5–35)

3,986 (2,920–10,037)

0.001

GM-CSF (pg/ml)

<2 (<2–39)

<2 (<2–28)

0.125


Results are medians, with ranges in parentheses. Concentrations of all mediators were determined by ELISA as described in the Materials and methods section. GM-CSF, granulocyte/macrophage colony-stimulating factor; MCP-1, monocyte chemoattractant protein-1; sICAM-1, soluble intracellular adhesion molecule-1; VEGF, vascular endothelial growth factor.

Berckmans et al. Arthritis Research & Therapy 2005 7:R536-R544   doi:10.1186/ar1706

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