Table 8

FBAT-e analyses considering 108 ankylosing spondylitis nuclear families (94 pedigrees, 425 persons) in which both affected men and women are present in each family: summary of the results using setafftrait 1 -1 0

Marker

Allele

Allele frequency

Number of informative families

Z score

P


Additive model: biallelic test


D5S1953

1

0.56

39

0.77

0.437

rs26307

C

0.90

10

0.50

0.617

rs27356

C

0.77

17

0.15

0.875

3088132

C

0.21

13

0.63

0.527

rs153929

G

0.23

32

0.81

0.418

rs258215

T

0.49

21

1.62

0.104

rs28006

T

0.29

27

2.81

0.004*

rs25957

G

0.32

22

2.37

0.017*

ANKH-OR

1

0.48

51

0.25

0.801

D5S1991

2

0.50

48

0.13

0.891

D5S1954

2

0.33

31

1.13

0.254


Recessive model: biallelic test


D5S1953

2

0.44

31

-1.34

0.177

rs26307

C

0.79

19

1.00

0.314

rs27356

C

0.80

20

1.17

0.239

3088132

G

0.79

14

-0.26

0.788

rs153929

G

0.23

10

1.06

0.288

rs258215

A

0.51

12

-2.49

0.012*

rs28006

C

0.71

20

-2.344

0.019*

rs25957

C

0.67

15

-1.97

0.048*

ANKH-OR

1

0.48

27

0.83

0.406

D5S1991

2

0.49

29

0.98

0.322

D5S1954

1

0.66

31

-1.67

0.093


*Statistically significant findings. FBAT, family-based association testing.

Tsui et al. Arthritis Research & Therapy 2005 7:R513-R525   doi:10.1186/ar1701

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