Table 8 |
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|
FBAT-e analyses considering 108 ankylosing spondylitis nuclear families (94 pedigrees, 425 persons) in which both affected men and women are present in each family: summary of the results using setafftrait 1 -1 0 |
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|
Marker |
Allele |
Allele frequency |
Number of informative families |
Z score |
P |
|
|
|||||
|
Additive model: biallelic test |
|||||
|
|
|||||
|
D5S1953 |
1 |
0.56 |
39 |
0.77 |
0.437 |
|
rs26307 |
C |
0.90 |
10 |
0.50 |
0.617 |
|
rs27356 |
C |
0.77 |
17 |
0.15 |
0.875 |
|
3088132 |
C |
0.21 |
13 |
0.63 |
0.527 |
|
rs153929 |
G |
0.23 |
32 |
0.81 |
0.418 |
|
rs258215 |
T |
0.49 |
21 |
1.62 |
0.104 |
|
rs28006 |
T |
0.29 |
27 |
2.81 |
0.004* |
|
rs25957 |
G |
0.32 |
22 |
2.37 |
0.017* |
|
ANKH-OR |
1 |
0.48 |
51 |
0.25 |
0.801 |
|
D5S1991 |
2 |
0.50 |
48 |
0.13 |
0.891 |
|
D5S1954 |
2 |
0.33 |
31 |
1.13 |
0.254 |
|
|
|||||
|
Recessive model: biallelic test |
|||||
|
|
|||||
|
D5S1953 |
2 |
0.44 |
31 |
-1.34 |
0.177 |
|
rs26307 |
C |
0.79 |
19 |
1.00 |
0.314 |
|
rs27356 |
C |
0.80 |
20 |
1.17 |
0.239 |
|
3088132 |
G |
0.79 |
14 |
-0.26 |
0.788 |
|
rs153929 |
G |
0.23 |
10 |
1.06 |
0.288 |
|
rs258215 |
A |
0.51 |
12 |
-2.49 |
0.012* |
|
rs28006 |
C |
0.71 |
20 |
-2.344 |
0.019* |
|
rs25957 |
C |
0.67 |
15 |
-1.97 |
0.048* |
|
ANKH-OR |
1 |
0.48 |
27 |
0.83 |
0.406 |
|
D5S1991 |
2 |
0.49 |
29 |
0.98 |
0.322 |
|
D5S1954 |
1 |
0.66 |
31 |
-1.67 |
0.093 |
|
|
|||||
|
*Statistically significant findings. FBAT, family-based association testing. |
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|
Tsui et al. Arthritis Research & Therapy 2005 7:R513 doi:10.1186/ar1701 |
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