Table 7 |
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|
FBAT-e analyses considering 226 ankylosing spondylitis nuclear families (201 pedigrees, 894 persons): summary of results using setafftrait 1 -1 0 |
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|
Marker |
Allele |
Allele frequency |
Number of informative families |
Z score |
P |
|
|
|||||
|
Additive model: biallelic test |
|||||
|
|
|||||
|
D5S1953 |
1 |
0.56 |
63 |
0.15 |
0.879 |
|
rs26307 |
C |
0.81 |
35 |
1.29 |
0.195 |
|
rs27356 |
C |
0.80 |
39 |
1.12 |
0.261 |
|
3088132 |
G |
0.79 |
29 |
0.69 |
0.489 |
|
rs153929 |
G |
0.24 |
52 |
0.61 |
0.541 |
|
rs258215 |
T |
0.41 |
41 |
0.46 |
0.638 |
|
rs28006 |
T |
0.26 |
44 |
1.69 |
0.090 |
|
rs25957 |
G |
0.23 |
39 |
0.90 |
0.366 |
|
ANKH-OR |
1 |
0.48 |
80 |
0.20 |
0.841 |
|
D5S1991 |
1 |
0.52 |
80 |
0.29 |
0.769 |
|
D5S1954 |
2 |
0.36 |
63 |
1.21 |
0.227 |
|
|
|||||
|
Recessive model: biallelic test |
|||||
|
|
|||||
|
D5S1953 |
1 |
0.56 |
46 |
-0.89 |
0.370 |
|
rs26307 |
C |
0.81 |
37 |
2.17 |
0.030* |
|
rs27356 |
C |
0.80 |
41 |
1.91 |
0.055 |
|
3088132 |
G |
0.79 |
29 |
1.17 |
0.240 |
|
rs153929 |
G |
0.24 |
18 |
0.55 |
0.582 |
|
rs258215 |
A |
0.59 |
29 |
-0.75 |
0.453 |
|
rs28006 |
C |
0.74 |
40 |
-1.13 |
0.186 |
|
rs25957 |
C |
0.77 |
36 |
-0.66 |
0.507 |
|
ANKH-OR |
2 |
0.52 |
50 |
-0.34 |
0.733 |
|
D5S1991 |
2 |
0.49 |
52 |
-0.28 |
0.779 |
|
D5S1954 |
1 |
0.64 |
61 |
-1.53 |
0.126 |
|
|
|||||
|
*Statistically significant findings. FBAT, family-based association testing. |
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|
Tsui et al. Arthritis Research & Therapy 2005 7:R513 doi:10.1186/ar1701 |
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