Table 7

FBAT-e analyses considering 226 ankylosing spondylitis nuclear families (201 pedigrees, 894 persons): summary of results using setafftrait 1 -1 0

Marker

Allele

Allele frequency

Number of informative families

Z score

P


Additive model: biallelic test


D5S1953

1

0.56

63

0.15

0.879

rs26307

C

0.81

35

1.29

0.195

rs27356

C

0.80

39

1.12

0.261

3088132

G

0.79

29

0.69

0.489

rs153929

G

0.24

52

0.61

0.541

rs258215

T

0.41

41

0.46

0.638

rs28006

T

0.26

44

1.69

0.090

rs25957

G

0.23

39

0.90

0.366

ANKH-OR

1

0.48

80

0.20

0.841

D5S1991

1

0.52

80

0.29

0.769

D5S1954

2

0.36

63

1.21

0.227


Recessive model: biallelic test


D5S1953

1

0.56

46

-0.89

0.370

rs26307

C

0.81

37

2.17

0.030*

rs27356

C

0.80

41

1.91

0.055

3088132

G

0.79

29

1.17

0.240

rs153929

G

0.24

18

0.55

0.582

rs258215

A

0.59

29

-0.75

0.453

rs28006

C

0.74

40

-1.13

0.186

rs25957

C

0.77

36

-0.66

0.507

ANKH-OR

2

0.52

50

-0.34

0.733

D5S1991

2

0.49

52

-0.28

0.779

D5S1954

1

0.64

61

-1.53

0.126


*Statistically significant findings. FBAT, family-based association testing.

Tsui et al. Arthritis Research & Therapy 2005 7:R513-R525   doi:10.1186/ar1701

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