Table 6

HBAT-e analyses using ANKH markers in four haplotype blocks defined in HapMap

Markers in the haplotype block

AS nuclear families (n = 226)

Testing specifically for affected women

Testing specifically for affected men

Additive model

rs26307, rs27356

[C,C]; 0.78; 39; 0.04

NS

[C,C]; 0.79; 24; 0.014

3088132, rs153929

NS

NS

NS

rs28006, rs25957

NS

[T,G]; 0.25; 19; 0.007

NS

ANKH-OR, D5S1991

[1,2]; 0.43; 57; 0.013

NS

NS

Recessive/dominant model

rs26307, rs27356

[C,C]; 0.78; 40; 0.02

NS

[C,C]; 0.79; 25; 0.004*

3088132, rs153929

[G,A]; 0.70; 32; 0.02

NS

NS

rs28006, rs25957

NS

[C,C]; 0.71; 18; 0.004*

NS

ANKH-OR, D5S1991

NS

NS

NS


Data are expressed as [allele]; allele frequency; number of informative families; P value.

*Significant P value after Bonferroni correction. (Because eight tests [four haplotypes and two models] were carried out in the haplotype-based association testing [HBAT]-e analyses, P < 0.00625 [0.05/8] is considered statistically significant.) AS, ankylosing spondylitis; NS, not significant.

Tsui et al. Arthritis Research & Therapy 2005 7:R513-R525   doi:10.1186/ar1701

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