Table 6 |
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|
HBAT-e analyses using ANKH markers in four haplotype blocks defined in HapMap |
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|
Markers in the haplotype block |
AS nuclear families (n = 226) |
Testing specifically for affected women |
Testing specifically for affected men |
|
Additive model |
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|
rs26307, rs27356 |
[C,C]; 0.78; 39; 0.04 |
NS |
[C,C]; 0.79; 24; 0.014 |
|
3088132, rs153929 |
NS |
NS |
NS |
|
rs28006, rs25957 |
NS |
[T,G]; 0.25; 19; 0.007 |
NS |
|
ANKH-OR, D5S1991 |
[1,2]; 0.43; 57; 0.013 |
NS |
NS |
|
Recessive/dominant model |
|||
|
rs26307, rs27356 |
[C,C]; 0.78; 40; 0.02 |
NS |
[C,C]; 0.79; 25; 0.004* |
|
3088132, rs153929 |
[G,A]; 0.70; 32; 0.02 |
NS |
NS |
|
rs28006, rs25957 |
NS |
[C,C]; 0.71; 18; 0.004* |
NS |
|
ANKH-OR, D5S1991 |
NS |
NS |
NS |
|
|
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|
Data are expressed as [allele]; allele frequency; number of informative families; P value. *Significant P value after Bonferroni correction. (Because eight tests [four haplotypes and two models] were carried out in the haplotype-based association testing [HBAT]-e analyses, P < 0.00625 [0.05/8] is considered statistically significant.) AS, ankylosing spondylitis; NS, not significant. |
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Tsui et al. Arthritis Research & Therapy 2005 7:R513 doi:10.1186/ar1701 |
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