Table 3

FBAT-e analyses conducted in 226 ankylosing spondylitis nuclear families (201 pedigrees, 894 persons)

Marker

Allele

Allele frequency

Number of informative families

Z score

P

Additive model: biallelic test

D5S1953

2

0.45

54

0.57

0.569

rs26307

C

0.81

35

1.73

0.084

rs27356

C

0.80

39

2.54

0.011*

3088132

G

0.79

28

1.28

0.198

rs153929

A

0.76

48

1.61

0.107

rs258215

A

0.59

43

1.58

0.113

rs28006

C

0.74

34

1.62

0.104

rs25957

C

0.76

36

2.02

0.043*

ANKH-OR

1

0.47

59

1.62

0.105

D5S1991

2

0.48

58

1.33

0.181

D5S1954

1

0.64

54

0.65

0.515

Recessive model: biallelic test

D5S1953

2

0.43

48

0.45

0.683

rs26307

C

0.80

40

1.49

0.137

rs27356

C

0.79

44

2.32

0.020*

3088132

G

0.79

31

1.19

0.233

rs153929

A

0.76

50

1.86

0.062

rs258215

A

0.58

32

1.55

0.120

rs28006

C

0.74

37

1.46

0.142

rs25957

C

0.76

38

1.65

0.098

ANKH-OR

2

0.52

37

-2.20

0.027*

D5S1991

1

0.52

45

-1.96

0.050*

D5S1954

1

0.64

54

0.65

0.517

*Statistically significant findings. FBAT, family-based association testing.

Tsui et al. Arthritis Research & Therapy 2005 7:R513   doi:10.1186/ar1701