Table 2

T cell receptor Vα24 usage in peripheral blood mononuclear cells, synovial fluid mononuclear cells and synovial tissue from rheumatoid arthritis patients

Vα24

Vβ11


PBMCs

SFMCs

ST

PBMCs

SFMCs

ST


RA 1

mono

mono

NA

oligo (2)

mono

NA

RA 2

mono

poly

oligo (2)

mono

poly

oligo (2)

RA 3

mono

oligo (2)

NA

Poly

oligo (2)

NA

RA 4

poly

poly

NA

Poly

poly

NA

RA 5

oligo (3)

NA

mono

mono

NA

mono

RA 6

poly

NA

poly

poly

NA

poly

RA 7

oligo (3)

NA

mono

poly

NA

oligo (3)


The clonality of the T-cell receptor (TCR) Vα24 family was assessed by CDR3 spectratyping of peripheral blood mononuclear cells (PBMCs), synovial fluid mononuclear cells (SFMCs) and synovial tissue (ST) from rheumatoid arthritis (RA) patients. (See Fig. 1 for representative monoclonal [panel a], oligoclonal [panel b] and polyclonal [panel c] profiles.) mono, monoclonal profile; NA, not available; oligo, oligoclonal profile; poly, polyclonal profile.

Linsen et al. Arthritis Research & Therapy 2005 7:R493-R502   doi:10.1186/ar1695

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