Cytokine profile of CD4+ and CD4- natural killer T (NKT) cell lines derived from peripheral blood mononuclear cells from rheumatoid arthritis (RA) patients and healthy control individuals. Vα24+ cells of α-galactosylceramide (α-GalCer) stimulated, 14-day-old cultures from nine healthy control individuals and nine RA patients were isolated using biomagnetic selection. The cytokine profile of (a) CD4+ and (b) CD4- NKT cells was assessed by intracellular staining. Error bars indicate standard error of the mean. *P < 0.05.
Linsen et al. Arthritis Research & Therapy 2005 7:R493-R502 doi:10.1186/ar1695