Arthritis Research & Therapy

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Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity

Karin Lundberg*, Suzanne Nijenhuis, Erik R Vossenaar, Karin Palmblad, Walter J van Venrooij, Lars Klareskog, AJW Zendman and Helena E Harris

Arthritis Research & Therapy 2005, 7:R458-R467 doi:10.1186/ar1697

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Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis

Hirofumi Shoda, Keishi Fujio, Mihoko Shibuya, Tomohisa Okamura, Shuji Sumitomo, Akiko Okamoto, Tetsuji Sawada, Kazuhiko Yamamoto Arthritis Research & Therapy 2011, 13:R191 (22 November 2011)

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Smoking and nicotine exposure delay development of collagen-induced arthritis in mice

Sofia S Lindblad, Piotr Mydel, Ing-Marie Jonsson, Robert M Senior, Andrej Tarkowski, Maria Bokarewa Arthritis Research & Therapy 2009, 11:R88 (11 June 2009)

Contrary to results from epidemiological studies, exposure to cigarette smoke delays the onset and slows the progression of collagen-induced arthritis in mice, and nicotine may alleviate inflammatory responses.

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Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

Xiaoyan Zhao, Nwora Okeke, Orr Sharpe, Franak M Batliwalla, Annette T Lee, Peggy P Ho, Beren H Tomooka, Peter K Gregersen, William H Robinson Arthritis Research & Therapy 2008, 10:R94 (18 August 2008)

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Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis

Therese Östberg, Heidi Wähämaa, Karin Palmblad, Norimasa Ito, Pernilla Stridh, Maria Shoshan, Michael T Lotze, Helena Harris, Ulf Andersson Arthritis Research & Therapy 2008, 10:R1 (7 January 2008)

Nuclear sequestration of HMGB1 - a protein that promotes inflammation when released extracellularly - may have potential in the treatment of arthritis, studies in a mouse model suggest.

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Presence of antibodies against cyclic citrullinated peptides in patients with 'rhupus': a cross-sectional study

Luis M Amezcua-Guerra, Rashidi Springall, Ricardo Marquez-Velasco, Lorena Gómez-García, Angélica Vargas, Rafael Bojalil Arthritis Research & Therapy 2006, 8:R144 (25 August 2006)