Table 3

Changes (fold change relative to day 0) in cytokine protein concentrations during rat AIA

Time point

IL-1β

IL-6

TNF-α

IL-2

IFN-γ

IL-4

IL-10

Inguinal lymph node

Day 0

1.00 (0.27)

1.00 (0.26)

1.00 (0.26)

1.00 (0.31)

1.00 (0.28)

1.00 (0.25)

1.00 (0.20)

6 hours

1.67 (0.60)

0.98 (0.38)

1.93 (0.78)

1.06 (0.31)

0.98 (0.25)

1.38 (0.55)

1.60 (0.32)

Day 1

1.74 (0.58)

0.59 (0.42)

2.53 (0.78)

1.31 (0.45)

1.14 (0.34)

1.86 (0.72)

2.18* (0.49)

Day 3

1.24 (0.29)

0.40 (0.21)

1.38 (0.28)

0.66 (0.12)

0.55 (0.11)

0.53 (0.28)

1.41 (0.24)

Day 6

1.86* (0.41

0.10* (0.10)

1.87 (0.38)

0.69 (0.14)

0.81 (0.12)

0.91 (0.27)

0.89 (0.17)

Spleen

Day 0

1.00 (0.12)

1.00 (0.41)

1.00 (0.10)

1.00 (0.23)

1.00 (0.13)

1.00 (0.12)

1.00 (0.05)

6 hours

0.75 (0.09)

0.32 (0.14)

0.61* (0.04)

0.70 (0.07)

0.78 (0.04)

0.77 (0.04)

0.94 (0.06)

Day 1

0.72 (0.11)

0.41 (0.17)

0.95 (0.13)

0.84 (0.16)

0.81 (0.07)

0.80 (0.08)

0.87 (0.08)

Day 3

0.81 (0.06)

0.24 (0.14)

1.07 (0.08)

0.70 (0.13)

0.71 (0.06)

0.85 (0.06)

0.90 (0.06)

Day 6

0.67 (0.06)

0.82*⁺ (0.07)

1.36 (0.21)

1.10*⁺ (0.13)

0.91⁺ (0.06)

0.96 (0.10)

0.99 (0.07)

Values (fold changes) are means (standard error of the mean) (n = 5 to 6 rats for each time point). AIA, antigen-induced arthritis. *P ≤ 0.05 in comparison with day 0; ⁺P ≤ 0.05 in comparison with the preceding date.

Pohlers et al. Arthritis Research & Therapy 2005 7:R445   doi:10.1186/ar1689