Table 1

Clinical and laboratory findings for 42 patients with ankylosing spondylitis treated with infliximab

Finding
BASDAI
BASMI
BASFI
PatGA
PhysGA
NRS-P
ESR (mm/h)
CRP (mg/l)

At time point 1a

Mean ± SD
2.5 ± 1.8**
2.7 ± 2.0*
2.9 ± 2.4**
2.6 ± 1.5**
2.6 ± 2.1**
2.6 ± 2.1**
10.5 ± 7.3**
3.1 ± 4.2**
Median
2.4
2.0
2.5
4.0
2.0
2.0
8.0
1.1
Range
0.0 - 6.8
0.0 - 7.0
0.0 - 8.3
0.0 - 8.0
0.0 - 4.0
0.0 - 7.0
2.0 - 32.0
0.0 - 19.0

At time point 2a

Mean ± SD
6.1 ± 1.4**
3.2 ± 2.2*
5.8 ± 1.8**
6.9 ± 2.1**
7.0 ± 1.5**
7.1 ± 1.7**
31.5 ± 29.7**
20.7 ± 23.7**
Median
6.2
3.0
5.7
7.0
7.0
7.0
23.0
14.0
Range
4.0 - 9.2
0.0 - 9.0
1.2 - 9.1
4.0 - 10.0
4.0 - 10.0
0.0 - 10.0
4.0 - 150.0
0.3 - 126.0

Change between time points 1 and 2

Mean ± SD
3.6 ± 1.7
0.5 ± 1.5
2.9 ± 2.0
4.3 ± 1.9
4.4 ± 1.8
4.5 ± 2.2
21.0 ± 29.7
17.6 ± 23.4
Median
3.6
0.5
2.5
4.0
4.0
4.0
12.0
11.5
Range
-1.2 - 6.7
-4.0 - 3.0
-0.5 - 7.8
-2.0 - 8.0
-2.0 - 8.0
-1.0 - 8.0
-6.0 - 146.0
-6.3 - 123.0

aTime point 1 is the time point at which infliximab treatment was discontinued; time point 2 is that when retreatment began. *P < 0.05, **P < 0.001, when means at time points 1 and 2 are compared. BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Function Index; BASMI, Bath Ankylosing Spondylitis Metrology Index; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; NRS-P, numerical rating scale for pain; PatGA, patient's global assessment; PhysGA, physician's global assessment; SD, standard deviation.

Baraliakos et al. Arthritis Research & Therapy 2005 7:R439   doi:10.1186/ar1693