Table 3

WAY-169916 gene-profiling experiment with spleen from rat adjuvant arthritis model

Av. control

Av. CFA

Av. CFA + WAY-169916

AFC CFA

AFC WAY-169916

Inhibition by WAY-169916 (%)


Transcription factors

CCAAT/enhancer binding protein (C/EBP), beta

16.8

39.8

19.6

2.37

0.49

87.6

NF-E2-related factor 2

14.2

30.3

19.6

2.13

0.65

66.2

Immune mediators

Mast cell protease 2

5.3

11.8

5.9

2.20

0.50

91.4

Arachidonate 5-lipoxygenase-activating protein

18.9

46.5

23.9

2.46

0.51

82.0

Chemokine-like factor 1

10.5

28.9

18.9

2.75

0.65

54.3

Phospholipase A2, group IIA

33.8

71.7

60.3

2.12

0.84

30.0

Proteoglycan 2, bone marrow

27.6

147.4

59.1

5.34

0.40

73.7

Immune related

CD14 antigen

15.9

32.3

19.1

2.04

0.59

80.2

Peptidoglycan recognition protein

10.2

39.6

14.5

3.88

0.37

85.2

Lipopolysaccharide-binding protein

3.3

10.2

4.4

3.10

0.43

83.6

IL-1 receptor, type II

2.2

8.1

3.5

3.71

0.44

76.8

Defensin RatNP-3 precursor

31.7

105.3

63.5

3.32

0.60

56.8

Suppressor of cytokine signalling 3

15.2

35.3

15.2

2.33

0.43

99.7

Complement component 3

13.3

28.4

24.2

2.14

0.85

27.6

Defensin NP-2 precursor

58.9

166.6

102.8

2.83

0.62

59.3

Defensin NP-4 precursor

54.1

164.9

104.7

3.05

0.64

54.3

Paired immunoglobulin-like receptor-B

11.0

22.7

18.3

2.07

0.81

37.6

25 oligoadenylate synthetase

24.6

51.4

24.8

2.09

0.48

99.2

Tumor necrosis factor receptor II

7.3

15.8

8.9

2.18

0.56

81.0

S100 calcium-binding protein A8 (calgranulin A)

52.2

184.5

91.5

3.54

0.50

70.3

S100 calcium-binding protein A9 (calgranulin B)

144.9

382.7

242.1

2.64

0.63

59.1

Ficolin B

42.3

121.1

74.7

2.86

0.62

58.9

Myelin and lymphocyte protein

11.8

27.6

19.9

2.34

0.72

49.1

Protease

Matrix metalloproteinase 9

2.0

8.4

3.5

4.24

0.42

75.8

Chymase 1

2.9

9.2

5.1

3.16

0.56

64.8

Transport

Monocarboxylate transporter

10.3

24.4

10.0

2.38

0.41

102.3

Lipocalin 2

16.3

55.3

33.0

3.39

0.60

57.1

Acute phase

Haptoglobin

10.5

37.5

12.9

3.58

0.34

90.9

Metabolism

Uridine phosphorylase I

8.9

32.8

9.1

3.68

0.28

99.3

Guanine deaminase

17.8

39.5

20.7

2.21

0.52

86.9

Microsomal glutathione S-transferase 1

40.0

87.6

51.2

2.19

0.58

76.6

GTP cyclohydrolase 1

11.6

25.5

23.6

2.20

0.93

13.8

Hepatic steroid hydroxylase II A2

9.0

18.7

21.5

2.07

1.15

-29.0

Adhesion

C-CAM4 protein

11.5

24.5

16.0

2.12

0.65

65.6

Fibronectin 1

57.2

116.6

91.3

2.04

0.78

42.6

Unknown function

Expressed sequence tag

20.0

41.5

25.1

2.08

0.61

76.1


AFC, average fold change; Av., average; CFA, complete Freund's adjuvant.

Keith et al. Arthritis Research & Therapy 2005 7:R427-R438   doi:10.1186/ar1692

Open Data